Cerebelum 3 (Left)

Overview

The AAL2 region “Cerebelum 3 (Left)” corresponds to lobule III of the left cerebellar hemisphere, a part of the anterior cerebellum located superiorly and rostrally within the cerebellar vermis–hemisphere complex. This lobule is primarily associated with sensorimotor processing, receiving input from spinal and cortical pathways and contributing to fine-tuning of limb and axial movements, postural control, and coordination. Histologically, it exhibits the canonical cerebellar cortical organization, with a layered structure of molecular, Purkinje cell, and granular layers, and outputs via deep cerebellar nuclei to brainstem and thalamic motor circuits. There is no direct Wikipedia article for “Cerebelum 3 (Left),” but it is part of the anterior Cerebellum.

The left Cerebelum 3 region in the AAL2 atlas, part of the anterior cerebellar hemisphere, has been implicated in genetic studies primarily through imaging GWAS that link cerebellar volume and morphology to specific loci rather than to this subregion alone. Large-scale GWAS of cerebellar structure have identified associations with genes involved in neurodevelopment, synaptic function, and neuronal migration (e.g., variants near PAX6, FOXP2, CADM2, and genes in glutamatergic and GABAergic pathways), which influence volumetric measures across cerebellar lobules, including superior hemispheric regions encompassing Cerebelum 3 (Left). Cerebellar genetics is further implicated in neurodevelopmental and psychiatric conditions such as autism spectrum disorder, schizophrenia, ADHD, and mood disorders, where risk variants (for example in CNTNAP2, SHANK3, and other synaptic genes) are associated with altered cerebellar connectivity and structure, though most studies do not isolate Cerebelum 3 specifically. In motor coordination disorders and ataxias, pathogenic mutations in genes such as CACNA1A, ATXN1/2/3, and others lead to degenerative changes across anterior cerebellar regions, likely including this lobular area. Overall, genetic associations to the left Cerebelum 3 region are inferred from broader cerebellar or lobular phenotypes in imaging-genetic and disease studies, rather than from GWAS targeting this specific AAL2-defined parcel.

Overview generated by GPT-4o (2026).

Region ID: 9021
Hemisphere: left
Atlas: AAL2

Cerebelum 3 (Left) – Black Background (Full Brain)

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Cerebelum 3 (Left) – White Background (Full Brain)

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Cerebelum 3 (Left) – Black Background (Hemisphere)

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Cerebelum 3 (Left) – White Background (Hemisphere)

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Triplanar View – T1 Background

Triplanar View – Ghost Brain