The right Cerebelum 4 5 (Right) region in the AAL2 atlas corresponds to lobules IV and V of the anterior lobe of the right cerebellar hemisphere, which are primarily involved in sensorimotor processing and the fine-tuning of voluntary movements. These lobules receive extensive input from spinal and cortical motor pathways via the cerebellar peduncles and contribute to the regulation of muscle tone, posture, and the timing and coordination of limb movements. Functionally, activity in this region is associated with execution and adaptation of motor tasks, and lesions can lead to ataxia, dysmetria, and impaired balance. There is no direct Wikipedia article for “Cerebelum 4 5 (Right)” as defined in AAL2; a closely related structure is described under Cerebellum.
The right Cerebellum 4–5 region in the AAL2 atlas broadly overlaps lobules IV–V of the cerebellar anterior lobe, which have been implicated in large-scale imaging–genetics and GWAS-based brain-structure studies rather than in region-specific candidate gene work. Multimodal GWAS of cerebellar volume and lobular morphology (e.g., ENIGMA, UK Biobank imaging genetics) have identified common variants in and near genes involved in neurodevelopment and synaptic function—such as KATNAL2, RELN, PAX5, ZNF804A, and loci in/around MAPT and CELSR3—associated with total and lobule-specific cerebellar volume, with some effects observed in anterior lobe regions that include or approximate right lobules IV–V. Polygenic overlap has been reported between cerebellar structure (including anterior lobules) and psychiatric or neurodevelopmental disorders such as schizophrenia, bipolar disorder, major depression, and autism spectrum disorder, as well as cognitive and motor traits, largely via shared genetic architecture rather than direct single-region GWAS hits. Additional links arise from imaging–genetics studies of task-based activation and resting-state connectivity, which suggest that genetic variants related to neurodevelopmental pathways and synaptic regulation contribute to individual differences in cerebellar engagement in motor, cognitive, and affective networks; however, current evidence rarely isolates the right Cerebellum 4–5 parcel specifically, instead implicating clusters that span neighboring cerebellar lobules.
Overview generated by GPT-4o (2026).
Region ID: 9032
Hemisphere: right
Atlas: AAL2
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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