The right Cerebellum Crus II (Right) in the AAL2 atlas corresponds to the lateral portion of the posterior cerebellar hemisphere within lobule VII, specifically the Crus II subdivision, on the right side. This region is part of the so‑called “cognitive” or “neocerebellar” zones of the cerebellum, heavily interconnected with prefrontal and parietal association cortices via the pontine nuclei and thalamus. Functional imaging and lesion studies implicate Crus II in higher-order processes such as working memory, language, executive control, and aspects of social cognition, in addition to fine-tuning complex motor and oculomotor behaviors. Its right-sided location is especially relevant for integration with left-hemisphere cortical language and praxis networks due to the predominantly crossed cerebrocerebellar connections. There is no direct link for this specific subregion; see instead Cerebellum.
The right Cerebellum Crus2 region, as defined in the AAL2 atlas, has been implicated in several imaging genetics and GWAS studies that link cerebellar morphology and functional connectivity to cognitive, affective, and neurodevelopmental traits. Large-scale brain MRI GWAS (e.g., ENIGMA, UK Biobank) have identified common variants near genes such as KIAA0586, DLG2, and MAPT that influence cerebellar volume and cortical–cerebellar connectivity, with Crus2 often emerging in networks related to higher-order cognitive and language processes. Polygenic risk for schizophrenia, bipolar disorder, and major depressive disorder has been associated with altered cerebellar structure and activation, including Crus2, in resting-state and task fMRI studies, although specific locus-to-region mappings remain limited. Variants linked to autism spectrum disorder and attention-deficit/hyperactivity disorder, including those in synaptic and neurodevelopmental genes (e.g., CNTNAP2, SHANK3, and FOXP2-related pathways), have been associated with disrupted fronto-cerebellar circuits involving Crus2 in functional connectivity and volumetric analyses. Additionally, GWAS of general cognitive ability and educational attainment have reported that polygenic scores for these traits correlate with Crus2 volume and connectivity within the default mode and language networks, suggesting that genetic influences on cerebellar Crus2 contribute to individual differences in executive function, working memory, and language-related processing.
Overview generated by GPT-4o (2026).
Region ID: 9012
Hemisphere: right
Atlas: AAL2
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).