The right Frontal Mid 2 region in the AAL2 atlas corresponds to a mid-portion of the right middle frontal gyrus, a dorsolateral frontal cortical area involved in higher-order executive functions, working memory, attentional control, and goal-directed behavior. This region participates in the frontoparietal control network, integrating sensory and mnemonic information to support planning, decision-making, and cognitive flexibility, and shows strong connectivity with prefrontal, parietal, and subcortical structures. Functionally, activity in this area is commonly observed during tasks requiring manipulation of information in working memory, inhibition of prepotent responses, and the regulation of complex behavior. There is no direct link for “Frontal Mid 2 (Right)”; a related structure is the Middle frontal gyrus.
The right Frontal Mid 2 region in the AAL2 atlas corresponds to the mid-part of the right middle frontal gyrus, a core component of the dorsolateral prefrontal cortex, and has been implicated in genetic studies of cognition, psychiatric risk, and brain structure. GWAS of cortical thickness and surface area have repeatedly identified common variants near genes such as MAPT, KCNK2, CENPW, and others that influence middle frontal morphology, including right-sided prefrontal measures overlapping this parcel. Large-scale imaging genetics consortia (e.g., ENIGMA, UK Biobank) have shown that polygenic scores for intelligence, educational attainment, and working memory performance correlate with structural and functional variation in the middle frontal gyrus, with the right hemisphere often implicated in executive control and attention. Psychiatric GWAS and post-GWAS imaging studies have linked schizophrenia, bipolar disorder, major depression, ADHD, and autism spectrum disorder risk variants to altered activation or volume in right middle frontal regions during tasks involving cognitive control, emotion regulation, or social cognition. In addition, genetic predisposition to substance use (alcohol, nicotine, cannabis), impulsivity, and risk-taking has been associated with reduced volume or altered connectivity in right dorsolateral prefrontal areas that substantially overlap Frontal Mid 2 (Right), supporting a genetically influenced role of this region in self-control, decision-making, and vulnerability to neuropsychiatric conditions.
Overview generated by GPT-4o (2026).
Region ID: 2202
Hemisphere: right
Atlas: AAL2
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Full Quality Version: Download MP4
Full Quality Version: Download MP4
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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