The left Occipital Sup (Superior Occipital Gyrus, left) in the AAL2 atlas is a cortical region located in the dorsal part of the occipital lobe, bordering parietal areas such as the superior parietal lobule and involved in higher-order visual processing. It contributes to visuospatial integration, motion perception, and the transformation of visual inputs into representations used for spatial attention and visually guided actions, interfacing with dorsal visual stream networks that project toward parietal and frontal cortices. Neuronal populations in this gyrus participate in processing complex visual features and coordinating eye–hand interactions, and the region is interconnected with extrastriate visual areas and parietal association cortices. There is no direct link for “Superior Occipital Gyrus,” but it is part of the occipital lobe: Occipital lobe.
The left Superior Occipital region (Occipital Sup L) in the AAL2 atlas, corresponding to dorsal aspects of the occipital cortex involved in visual processing and visuospatial integration, has been implicated indirectly rather than as a primary locus in genetic studies. Large neuroimaging GWAS from consortia such as ENIGMA and UK Biobank have identified multiple common variants associated with occipital cortical surface area and thickness, including loci near genes involved in neuronal development and synaptic signaling (e.g., variants in or near HDAC9, TCF4, CUX1, and genes along the Wnt and axon-guidance pathways), though these effects are typically distributed across bilateral occipital regions and not specific to the left superior occipital gyrus. Polygenic risk scores for psychiatric disorders (schizophrenia, major depression, bipolar disorder, autism spectrum disorder) and neurodevelopmental traits (intelligence, educational attainment) have been associated with structural and functional variation in occipital cortex, including altered visual network connectivity, but such findings usually treat the occipital lobe as a network node rather than singling out the left Occipital Sup region. Occipital visual areas, including superior portions, show structural or functional abnormalities in genetic epilepsy syndromes with visual aura and in migraine, where GWAS-identified loci (e.g., near TRPM8, PRDM16, LRP1) influence cortical excitability and sensory processing, yet regional analyses rarely report effects at the granularity of the AAL2 Occipital Sup L parcel. Overall, current genetic evidence links variability in the left superior occipital cortex to broad polygenic influences on brain development, cognition, vision, and psychiatric risk, but no robust, region-specific genetic associations unique to the AAL2 “Occipital Sup L” region have been consistently established.
Overview generated by GPT-4o (2026).
Region ID: 5101
Hemisphere: left
Atlas: AAL2
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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