OFClat (Right)

Overview

The right OFClat region (Right lateral orbitofrontal cortex) in the AAL2 atlas corresponds to the lateral portion of the orbitofrontal cortex situated on the ventral surface of the frontal lobe, overlying the orbits. This cortical area is implicated in reward evaluation, decision-making, emotional regulation, and adaptive learning, particularly in updating stimulus–reward associations and modulating behavior based on changing reinforcement contingencies. It forms part of the broader prefrontal and limbic circuitry, receiving multimodal sensory input and projecting to subcortical structures involved in motivation and affect. There is no direct Wikipedia article for “Right OFClat,” but it is encompassed within the orbitofrontal cortex: Orbitofrontal cortex.

The right lateral orbitofrontal cortex (right OFClat) in the AAL2 atlas corresponds to lateral portions of the orbitofrontal cortex that have been repeatedly implicated in genetic and GWAS-based studies of psychiatric and behavioral traits, though typically under broader “orbitofrontal” or “frontal” cortical measures rather than atlas-specific labels. Large-scale imaging-genetics consortia (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in neurodevelopment, synaptic plasticity, and cortical patterning—such as those near or within GRIN2B, BDNF, SLC6A4, DRD2, and FOXP2—as associated with orbitofrontal structure or function, including cortical thickness, volume, or activity patterns encompassing the right lateral OFC. GWAS of risk-taking, impulsivity, reward sensitivity, and decision-making have linked loci in dopaminergic, serotonergic, and glutamatergic pathways to variations in orbitofrontal activation, while polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and substance-use disorders correlate with altered right OFC morphology or connectivity. Moreover, genetic variants associated with obsessive–compulsive disorder, anxiety, and autism spectrum conditions often influence cortico-striato-thalamo-cortical circuits that prominently include the lateral OFC, with some studies highlighting right-lateralized effects. Overall, genetic associations with the right OFClat region converge on pathways regulating fronto-limbic development, neurotransmission, and reward-based learning, although precise locus-to-region specificity for this exact AAL2 parcel remains limited and is usually inferred from broader orbitofrontal or frontal lobe measures.

Overview generated by GPT-4o (2026).

Region ID: 2832
Hemisphere: right
Atlas: AAL2

OFClat (Right) – Black Background (Full Brain)

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OFClat (Right) – White Background (Full Brain)

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OFClat (Right) – Black Background (Hemisphere)

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OFClat (Right) – White Background (Hemisphere)

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Triplanar View – T1 Background

Triplanar View – Ghost Brain