OFCpost (Right)

Overview

The right OFCpost (Right) region in the AAL2 atlas corresponds to the posterior portion of the right orbitofrontal cortex, a ventral prefrontal area located on the inferior surface of the frontal lobe above the orbits. This region is implicated in reward valuation, outcome-based decision-making, and adaptive behavioral responses, integrating multimodal sensory inputs (including olfactory and gustatory signals) with internal state and contextual information to guide flexible goal-directed behavior. Cytoarchitectonically, it encompasses parts of Brodmann areas typically assigned to the orbitofrontal cortex and is interconnected with limbic structures such as the amygdala, ventral striatum, and hippocampus, as well as other prefrontal and sensory association regions, supporting its role in emotion, motivation, and the updating of stimulus–reward contingencies. There is no direct Wikipedia article for “right OFCpost”; a related structure is the Orbitofrontal cortex.

The right posterior orbitofrontal cortex (right OFCpost) in the AAL2 atlas corresponds to a posterior sector of the orbitofrontal cortex that has been implicated in several genetic and GWAS-based associations through its broader involvement in reward processing, affect regulation, and decision-making networks. Large-scale imaging–genetics consortia such as ENIGMA and UK Biobank report that common variants in genes influencing cortical thickness, surface area, and gyrification (for example in pathways involving synaptic development, neurogenesis, and extracellular matrix organization) show significant associations with orbitofrontal morphology, including right-lateralized regions. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder have been linked to structural and functional alterations in orbitofrontal territories encompassing the right posterior OFC, while alcohol and nicotine use GWAS highlight variants (e.g., in genes related to dopaminergic and glutamatergic transmission) that track with altered volume or activation in this region during reward or inhibitory-control tasks. Additional associations connect orbitofrontal measures, including right posterior aspects, with genetic risk for obesity and metabolic traits, as well as personality dimensions such as neuroticism and impulsivity, although specific single-locus findings for the exact AAL2 “OFCpost_R” parcel remain limited and are usually reported at the level of broader orbitofrontal or frontal lobe phenotypes rather than this precise subregion.

Overview generated by GPT-4o (2026).

Region ID: 2822
Hemisphere: right
Atlas: AAL2

OFCpost (Right) – Black Background (Full Brain)

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OFCpost (Right) – White Background (Full Brain)

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OFCpost (Right) – Black Background (Hemisphere)

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OFCpost (Right) – White Background (Hemisphere)

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Triplanar View – T1 Background

Triplanar View – Ghost Brain