The right Parietal Inf (Right) region in the AAL2 atlas corresponds to the right inferior parietal lobule, located in the posterior part of the parietal lobe, lateral to the intraparietal sulcus and superior to the temporal lobe. This region encompasses structures such as the supramarginal and angular gyri and is heavily involved in multimodal integration of sensory information, spatial attention, visuomotor coordination, language-related processes (including semantic processing and reading), and aspects of social cognition such as theory of mind. Functionally, the right inferior parietal lobule is particularly associated with attention reorienting, spatial neglect when lesioned, and integration of visual and somatosensory inputs for goal-directed actions. A closely related structure with a direct Wikipedia article is the Inferior parietal lobule.
The right inferior parietal lobule (IPL), corresponding to the AAL2 “Parietal Inf (Right)” region, has been implicated in multiple genetic and GWAS-based associations involving cortical structure, cognition, and neuropsychiatric risk. Large-scale imaging–genetics consortia (e.g., ENIGMA, UK Biobank) have identified common variants in genes related to neurodevelopment, synaptic function, and axon guidance—such as MIR137, PPP1R1B, HMGA2, and multiple loci near microtubule and cell-adhesion genes—that are associated with cortical thickness, surface area, and gyrification in inferior parietal regions, often with hemispheric asymmetry. Polygenic scores for general intelligence, educational attainment, and working memory show robust correlations with right IPL morphology and activation, suggesting a genetic contribution to parietal-based attentional and integrative functions. GWAS of schizophrenia, bipolar disorder, and major depressive disorder demonstrate overlapping polygenic influences on right IPL volume and connectivity, while autism spectrum disorder and ADHD studies link risk variants in synaptic and neurodevelopmental genes (e.g., CNTNAP2, CHD8-related networks) to altered inferior parietal structure and functional networks. Additional associations include genetic influences on right IPL involvement in Alzheimer’s disease and other dementias (APOE and related loci affecting parietal atrophy patterns), stroke and white-matter lesion burden, and traits such as handedness and language lateralization, indicating that the right inferior parietal cortex is a convergence zone for diverse, partly shared genetic architectures governing higher-order cognition and vulnerability to psychiatric and neurodegenerative conditions.
Overview generated by GPT-4o (2026).
Region ID: 6202
Hemisphere: right
Atlas: AAL2
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Full Quality Version: Download MP4
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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