The right Rectus (Right) region in the AAL2 atlas corresponds to the right gyrus rectus, a medial orbital frontal cortical area located on the ventral surface of the frontal lobe, adjacent to the olfactory sulcus and closely associated with the orbitofrontal cortex. This region is involved in higher-order cognitive and affective processes, including decision-making, reward evaluation, social cognition, and emotional regulation, often functioning within broader prefrontal and limbic networks. Structurally, it is part of the prefrontal cortex and receives input from limbic structures such as the amygdala and hippocampus, contributing to the integration of emotional and mnemonic information into goal-directed behavior. There is no direct link for “Right Rectus (Right)” as an AAL2 label; a related structure is the gyrus rectus of the frontal lobe: Gyrus rectus.
The right Rectus gyrus (medial orbitofrontal/ventromedial prefrontal region in AAL2) has been implicated in genetic studies largely through imaging‑genetics and GWAS of brain structure rather than direct region-specific association scans. Multivariate GWAS of cortical thickness and surface area in large cohorts (e.g., ENIGMA, UK Biobank) have identified common variants in loci such as 17q21.31 (including KANSL1), 15q14 (near C15orf53), and genes involved in neurodevelopment and synaptic function (e.g., CENPW, TCF4, DLG2) that influence medial orbitofrontal and adjacent frontal morphology, which often encompass Rectus parcels in AAL-derived parcellations. Polygenic risk for major depressive disorder, schizophrenia, and bipolar disorder has been associated with altered medial orbitofrontal/Rectus volume or thickness, suggesting shared genetic architecture between psychiatric liability and this region’s structure, though few studies isolate the right Rectus specifically. Genetic correlations have also been reported between medial orbitofrontal measures and traits such as neuroticism, cognitive performance, and risk-taking, indicating that variants modulating this region’s anatomy and function likely contribute to affective regulation and decision-making. Overall, known associations for the right Rectus in AAL2 arise indirectly from broader orbitofrontal or frontal cortex GWAS, rather than region-specific loci uniquely assigned to the right Rectus gyrus.
Overview generated by GPT-4o (2026).
Region ID: 2702
Hemisphere: right
Atlas: AAL2
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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