The right Temporal Inf (Right) region in the AAL2 atlas corresponds to the right inferior temporal gyrus, a ventral temporal lobe structure located on the lateral and basal surface of the temporal cortex, extending between the middle temporal gyrus superiorly and the occipitotemporal (fusiform) gyrus medially and inferiorly. Cytoarchitectonically, it encompasses high-order association cortex involved in complex visual processing, including object recognition, visual form perception, and aspects of semantic processing related to visual stimuli. This region receives convergent input from earlier visual areas and projects to widespread cortical association networks, contributing to the integration of visual information with memory and language systems. Lesions in the right inferior temporal gyrus have been associated with deficits in visual object recognition (agnosia) and disturbances in visual memory. There is no direct link for “Temporal Inf (Right)” as an AAL2 label; a closely related structure is the Inferior temporal gyrus.
The right inferior temporal gyrus (Right Temporal Inf) in the AAL2 atlas, a key region for object recognition, semantic processing, and visual memory, features prominently in imaging genetics and GWAS of brain structure and function but has relatively few locus-specific findings. Large neuroimaging GWAS consortia (e.g., ENIGMA, UK Biobank) have identified common variants associated with temporal lobe cortical thickness, surface area, and volume—particularly in or near genes such as MAPT, KIAA0586, WNT3, and others involved in neurodevelopment and synaptic function—although results are typically reported at the lobar or gyral level rather than specifically for right inferior temporal cortex. Genetic risk for Alzheimer’s disease (e.g., APOE ε4) and frontotemporal dementia has been repeatedly associated with atrophy and altered activation in temporal association cortices, including inferior temporal regions, and schizophrenia, autism spectrum disorder, and dyslexia GWAS and candidate-gene studies show convergent effects on temporal lobe structure and connectivity (for example, variants in CNTNAP2, FOXP2, GRIN2A, and complement pathway genes influencing temporal cortical morphology or language-related activation). Polygenic scores for cognitive performance, educational attainment, and general intelligence are associated with structural and functional variation in temporal cortices, with right-sided inferior temporal involvement in visuospatial and semantic tasks. Nonetheless, specific, robust GWAS hits uniquely tied to the right Temporal Inf parcel in AAL2 remain limited, and most genetic associations are reported for broader temporal regions or bilateral inferior temporal cortex rather than this single atlas-defined area.
Overview generated by GPT-4o (2026).
Region ID: 8302
Hemisphere: right
Atlas: AAL2
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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