The right Temporal Mid (Right) region in the AAL2 atlas corresponds primarily to the mid-portion of the right middle temporal gyrus, a lateral temporal lobe structure involved in auditory processing, language comprehension, semantic memory, and aspects of social cognition such as interpreting others’ actions and intentions. Cytoarchitectonically, this region comprises association cortex receiving multimodal inputs from auditory, visual, and parietal areas, and it contributes to the integration of lexical-semantic information and narrative processing. Functionally, the right middle temporal gyrus is also implicated in processing complex sounds, prosody, and certain aspects of visual motion and biological motion perception. A direct article for “Temporal Mid (Right)” does not exist; a closely related structure is the Middle temporal gyrus.
Genetic associations involving the right middle temporal gyrus (right Temporal Mid) in the AAL2 atlas emerge mainly from imaging genetics and neuropsychiatric GWAS. Variants in genes related to synaptic function and neurodevelopment (for example, BDNF, GRIN2B, and DISC1) have been linked to structural or functional alterations in the middle temporal gyrus, particularly in studies of schizophrenia, major depressive disorder, and autism spectrum disorder, where changes in temporal lobe cortical thickness or volume show heritable components and polygenic influences. Large-scale GWAS of brain morphology (such as ENIGMA and UK Biobank–based analyses) report that common variants in loci near genes like HMGA2, microtubule- and cytoskeleton-related genes, and cell-adhesion molecules contribute to interindividual variability in temporal lobe volume, including middle temporal regions, with modest effect sizes distributed across many loci. The right middle temporal gyrus has also been implicated in genetic studies of language and reading abilities (e.g., associations near DCDC2, KIAA0319, and other dyslexia-related genes) and social cognition traits, consistent with its role in semantic processing and social perception, although these associations are typically indirect and captured via imaging endophenotypes rather than region-specific GWAS hits. Overall, current evidence indicates that the genetic architecture influencing the right middle temporal region is highly polygenic and overlaps with risk architectures for neurodevelopmental and psychiatric disorders, but precise, region-specific genetic determinants for the right Temporal Mid as defined in AAL2 remain incompletely resolved.
Overview generated by GPT-4o (2026).
Region ID: 8202
Hemisphere: right
Atlas: AAL2
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Full Quality Version: Download MP4
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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