The right Temporal Sup (Right), corresponding to the right superior temporal gyrus, is a cortical region located on the lateral surface of the temporal lobe, extending from the temporal pole posteriorly along the Sylvian fissure. It encompasses primary and secondary auditory cortices (including Heschl’s gyrus and surrounding areas) and is critically involved in processing complex acoustic information, speech perception, and aspects of language comprehension, with right-hemisphere contributions particularly relevant for prosody and nonverbal auditory cues. This region also participates in multimodal integration and social cognition, including components of the superior temporal sulcus that support perception of biological motion and socially relevant signals. A related article is Superior temporal gyrus.
The right superior temporal gyrus (Right Temporal Sup in the AAL2 atlas) has been implicated in multiple genetic association studies, particularly in the context of language, social cognition, and psychosis-related traits. GWAS of brain structure have identified common variants near genes involved in neurodevelopment and synaptic function (such as CNTNAP2, FOXP2-related networks, and other cortical patterning genes) that influence cortical thickness, surface area, or volume in temporal regions encompassing the superior temporal gyrus. This region has been repeatedly linked to schizophrenia and psychosis through imaging genetics, where risk alleles in genes like ZNF804A, NRG1, and CACNA1C are associated with altered activation or connectivity of right superior temporal areas during auditory and language tasks. Genetic studies of autism spectrum disorder and social communication traits have associated variants in synaptic and cell-adhesion genes (including neurexin–neuroligin pathways and SHANK family members) with atypical structure or function of the superior temporal cortex, a key hub for social perception. Additionally, polygenic risk scores for disorders such as major depressive disorder, bipolar disorder, and Alzheimer’s disease have shown correlations with temporal-lobe morphometry, including the right superior temporal gyrus, suggesting that distributed genetic risk for neuropsychiatric and neurodegenerative conditions partly manifests through this region’s anatomy and connectivity.
Overview generated by GPT-4o (2026).
Region ID: 8112
Hemisphere: right
Atlas: AAL2
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Full Quality Version: Download MP4
Full Quality Version: Download MP4
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Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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