The bilateral Supramarginal Gyrus, anterior division, as defined in the Harvard-Oxford Cortical Structural Atlas (maxprob thr25, 1 mm), corresponds to the anterior portion of the supramarginal gyrus located in the inferior parietal lobule, wrapping around the posterior end of the lateral sulcus (Sylvian fissure). This region lies adjacent to the superior temporal gyrus and angular gyrus and is implicated in multimodal integration of auditory, somatosensory, and visual information. Functionally, it has been associated with phonological processing, language comprehension, articulation, and aspects of social cognition, including empathy and perspective-taking, as well as the integration of sensorimotor information relevant to tool use and action planning. There is no direct Wikipedia article for this exact subregion; a related structure is the Supramarginal gyrus.
The bilateral supramarginal gyrus, anterior division, as defined in the Harvard-Oxford cortical atlas, has been implicated in multiple genetic and GWAS-based findings that converge on language, social cognition, and psychiatric risk. Large-scale neuroimaging genetics consortia such as ENIGMA and UK Biobank have shown that variation in cortical thickness and surface area in this region is heritable and influenced by common variants in genes related to synaptic function, neuronal development, and glutamatergic signaling, including loci near or within genes such as BDNF, GRIN2B, and various potassium channel and cell-adhesion genes, although specific associations are often shared across temporoparietal regions rather than uniquely mapped to the supramarginal gyrus. GWAS of cortical morphology and functional connectivity have linked supramarginal gyrus metrics to polygenic risk for schizophrenia, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder, consistent with its role in language processing, social inference, and integration of multisensory information. Genetic correlations have also been reported between measures involving this region and cognitive traits such as general intelligence, reading ability, and educational attainment, as well as social-behavioral traits (e.g., empathic processing and theory-of-mind tasks), though these are typically part of broader temporoparietal and language-network findings rather than supramarginal-specific effects. Overall, current evidence suggests that common genetic variants influencing supramarginal gyrus structure and function contribute modestly and pleiotropically to risk for neurodevelopmental and psychiatric disorders and to individual differences in language and social cognition, with no single gene or variant uniquely defining the bilateral anterior supramarginal gyrus at present.
Overview generated by GPT-4o (2026).
Region ID: 19
Hemisphere: bilateral
Atlas: HarvardOxford cort maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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