The bilateral Cingulum (cingulate gyrus) L, as defined in the JHU ICBM labels 1mm Atlas, refers to the left-hemisphere segment of the cingulum white matter tract running within and adjacent to the cingulate gyrus, a medial cortical structure arching above the corpus callosum. This tract forms a major component of the limbic system’s connectivity, linking medial frontal, parietal, and temporal regions, including connections between the cingulate cortex, hippocampal formation, and other association cortices. Functionally, the cingulum supports integration of emotional, cognitive, and autonomic processes, and is implicated in attention, executive control, memory, and affective regulation. Structural or functional alterations in this region have been associated with neuropsychiatric and neurodegenerative conditions, including depression, schizophrenia, and Alzheimer’s disease. There is no direct Wikipedia article for the specific tract label, but it is closely related to the cortical structure Cingulate gyrus.
The bilateral cingulum (cingulate gyrus) from the JHU ICBM 1 mm atlas has been implicated in multiple imaging genetics and GWAS studies that link its microstructure and volume to specific genetic variants and neuropsychiatric traits. Diffusion MRI studies have associated cingulum fractional anisotropy and mean diffusivity with common variants in genes related to myelination, axonal guidance, and neurodevelopment (e.g., NTRK1/2, ROBO1/2, LINGO1, and ERBB4), as well as with polygenic risk scores for schizophrenia, major depressive disorder, and bipolar disorder, consistent with the cingulum’s role in fronto-limbic circuitry. Large consortia such as ENIGMA and UK Biobank–based GWAS have reported significant loci influencing cingulum white matter integrity and cingulate cortical thickness in or near genes involved in neuronal growth and synaptic function (including CNTNAP2, BDNF-related pathways, and several MHC-region markers), and these same loci often show pleiotropic associations with cognitive performance, educational attainment, and risk for disorders such as schizophrenia, ADHD, autism spectrum disorder, and Alzheimer’s disease. Structural and functional variation in the cingulate-cingulum complex has also been genetically linked to internalizing symptoms, neuroticism, pain sensitivity, and default mode network connectivity, reinforcing the view that this tract is a heritable substrate mediating genetic influences on affect regulation, cognition, and vulnerability to psychiatric and neurodegenerative disease.
Overview generated by GPT-4o (2026).
Region ID: 36
Hemisphere: bilateral
Atlas: JHU ICBM labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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