The bilateral cingulum (cingulate gyrus) R, as defined in the JHU ICBM tracts maxprob thr25 1mm atlas, refers to a major white matter association bundle running within the cingulate gyrus along the medial aspect of the cerebral hemispheres, arching over the corpus callosum and extending between frontal, parietal, and medial temporal regions. This tract is a key component of the limbic system, interconnecting structures involved in emotion, attention, memory, and executive control, including the cingulate cortex, hippocampal formation, and prefrontal areas. Functionally, the cingulum supports integration of cognitive and emotional information, contributes to default mode network activity, and is implicated in processes such as error monitoring, pain perception, and contextual memory. Related structures and functions are discussed under the Cingulum (brain).
The bilateral cingulum (cingulate gyrus) from the JHU ICBM tracts atlas has been repeatedly implicated in imaging genetics and GWAS of white-matter microstructure, with common variants influencing fractional anisotropy and related diffusion metrics in this tract, particularly in large consortia such as ENIGMA and UK Biobank. Genes involved in axonal guidance, myelination, and neuronal development (for example, NRG1, CNTNAP2, BDNF, and various cell adhesion and oligodendrocyte-related genes) have been associated with cingulum integrity, although specific loci often show modest, distributed effects. Altered cingulum microstructure has been genetically linked, via imaging–genetics mediation, to risk for major psychiatric and neurodevelopmental conditions including schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder, as well as to traits such as neuroticism, cognitive performance, and risk for dementia. Polygenic risk scores for these disorders and traits frequently correlate with cingulum diffusivity measures, suggesting that shared genetic architectures influence both disease liability and white-matter organization in this tract, even though no single variant or gene has been established as uniquely specific to the cingulum.
Overview generated by GPT-4o (2026).
Region ID: 6
Hemisphere: bilateral
Atlas: JHU ICBM tracts maxprob thr25 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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