The bilateral cingulum (hippocampus) L, as defined in the JHU ICBM tracts maxprob thr25 2mm atlas, is a left-hemisphere white matter tract running within the cingulum bundle that specifically courses along the parahippocampal gyrus and adjacent medial temporal lobe structures, connecting the hippocampal formation with other limbic and paralimbic regions. It forms part of the limbic connectivity network, supporting communication between the hippocampus, entorhinal cortex, cingulate cortex, and other medial cortical areas involved in memory processing, spatial navigation, and emotional regulation. Structurally, this tract consists of myelinated association fibers that contribute to the integration of mnemonic and affective information, and functionally it is implicated in episodic memory and in the coordination of distributed limbic activity. There is no single dedicated Wikipedia article for the “Cingulum (hippocampus)” subdivision, but it is part of the broader cingulum bundle: Cingulum (brain).
The bilateral cingulum (hippocampus) segment, as defined in the JHU ICBM tracts atlas, has been repeatedly implicated in genetic studies of white matter integrity, memory, and psychiatric risk, with GWAS identifying multiple loci influencing diffusion metrics (e.g., fractional anisotropy and mean diffusivity) in this tract. Common variants in genes involved in myelination and axonal guidance—such as those related to oligodendrocyte function and neurodevelopmental pathways—have shown associations with cingulum-hippocampal microstructure, including loci near genes like NRG1, CNTNAP2, and others highlighted in large-scale imaging genetics consortia (e.g., ENIGMA) for limbic and hippocampal-connected tracts. Altered genetic influences on this region’s integrity have been linked to risk for major depressive disorder, schizophrenia, bipolar disorder, and anxiety, where risk alleles in synaptic and neuroplasticity genes (including those near BDNF and CACNA1C) correlate with reduced integrity or aberrant connectivity within the hippocampal cingulum. Additionally, polygenic risk scores for Alzheimer’s disease and other cognitive decline phenotypes, including APOE-related risk, have been associated with microstructural changes in this tract, reflecting its role in episodic memory networks. Genetic effects on neuroticism, general cognitive ability, and educational attainment have also been reported to partly act through variability in limbic white matter tracts, including the cingulum-hippocampus segment, underscoring this region as a convergent substrate for heritable differences in emotion regulation and memory-related cognition.
Overview generated by GPT-4o (2026).
Region ID: 7
Hemisphere: bilateral
Atlas: JHU ICBM tracts maxprob thr25 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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