The bilateral GM Anterior intra-parietal sulcus hIP1 L (from the Juelich maxprob thr25 1mm atlas) is a cytoarchitectonically defined subregion of the human intraparietal sulcus located within the inferior parietal lobule, associated primarily with visuomotor integration, attention, and object-related processing such as grasping and manipulation. This area forms part of the broader intraparietal sulcus network implicated in transforming visual information into action-relevant coordinates and participates in dorsal stream functions such as spatial perception, eye–hand coordination, and the guidance of complex motor behavior. There is no direct Wikipedia article for hIP1; a related structure encompassing this region is the Intraparietal sulcus.
The anterior intra-parietal sulcus (hIP1) in the Juelich atlas, part of the broader intraparietal sulcus (IPS) system implicated in visuospatial attention, eye–hand coordination, and numerical and object processing, has been linked to genetic variation primarily through imaging genetics and GWAS of cortical morphology and cognitive traits rather than region-specific disease studies. Large-scale GWAS of brain structure (e.g., ENIGMA and UK Biobank) have identified loci near genes such as HMGA2, IGF1, KIAA0586, and others that influence parietal cortical thickness and surface area, encompassing IPS territories that include hIP1 L, with some of these loci also associated with general cognitive ability, educational attainment, and head/brain size. Functionally, IPS regions overlapping hIP1 have shown heritable activation patterns in twin and family studies during tasks of visuospatial attention, working memory, and numerical cognition, and genetic variants in dopaminergic and glutamatergic pathways (e.g., COMT, DRD2, GRIN2B) have been associated with task-related activation and connectivity in parietal attention networks that include the anterior IPS. In clinical genetics, parietal and IPS abnormalities, influenced by polygenic risk, are frequently reported in schizophrenia, ADHD, and autism spectrum disorder, and GWAS for these conditions often implicate genes affecting synaptic development and plasticity (e.g., CACNA1C, GRM3, CNTNAP2) whose effects on large-scale frontoparietal networks plausibly extend to hIP1. However, there are currently no well-established GWAS or candidate-gene findings that specifically and uniquely target bilateral GM anterior IPS hIP1 L as a distinct phenotype; genetic associations are inferred from parietal or intraparietal measures more broadly and from task-based activation in overlapping frontoparietal attention and visuospatial networks.
Overview generated by GPT-4o (2026).
Region ID: 1
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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