The bilateral GM Anterior intra-parietal sulcus hIP2 L region, as defined in the Juelich maxprob thr25 1 mm atlas, corresponds to a cytoarchitectonically and functionally characterized subregion of the human intraparietal sulcus located in the posterior parietal cortex. This area is implicated in visuomotor integration, object-directed actions (such as grasping), and higher-order spatial processing, and it participates in transforming visual information into motor commands for hand and eye movements. hIP2 lies within the broader intraparietal sulcus complex, which is part of the dorsal attention and fronto-parietal control networks involved in spatial attention, working memory for spatial information, and sensorimotor coordination. There is no direct Wikipedia article for hIP2; a related structure it is in is the Intraparietal sulcus.
The bilateral GM anterior intraparietal sulcus (hIP2 L) region, as defined in the Juelich maxprob thr25 1 mm atlas, is part of the lateral parietal cortex implicated in visuomotor integration, attention, and higher-order cognitive functions, and genetic associations arise largely from imaging-genetics and GWAS of cortical structure and function in parietal areas rather than hIP2 specifically. Large-scale consortia such as ENIGMA and UK Biobank have identified common variants in genes related to neurodevelopment, synaptic function, and axon guidance (e.g., BDNF, CADM2, MEF2C, CNTNAP2, and loci near MAU2, DAAM2, and CENPW) that influence parietal cortical thickness, surface area, and gyrification, with downstream associations to cognitive performance, educational attainment, and general intelligence; these traits frequently show structural correlates in intraparietal regions, though not at the resolution of the hIP2 subfield. Functional GWAS and polygenic score analyses link parietal activation patterns—including in intraparietal sulcus—during numerical cognition, working memory, and attention tasks to polygenic load for cognitive ability and psychiatric conditions such as schizophrenia, ADHD, and major depressive disorder, suggesting that genetic risk for these disorders partly manifests via altered parietal network structure and function. Additionally, parietal regions encompassing the intraparietal sulcus have been implicated in genetic studies of developmental dyscalculia, autism spectrum conditions with visuospatial and attentional phenotypes, and neurodegenerative disorders such as Alzheimer’s disease, where variants in APOE and other loci influence parietal cortical atrophy patterns. However, no GWAS to date has reported robust, hIP2-specific locus-level associations, and current genetic insights are inferred from broader parietal or intraparietal sulcus measures rather than this exact cytoarchitectonic subdivision.
Overview generated by GPT-4o (2026).
Region ID: 3
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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