The bilateral GM Anterior intra-parietal sulcus hIP2 R region, defined in the Juelich maxprob thr25 1mm atlas, corresponds to a cytoarchitectonically and functionally specific subdivision of the human intraparietal sulcus within the posterior parietal cortex, predominantly localized in the right hemisphere. It is implicated in sensorimotor integration, visuospatial attention, and object-directed actions such as grasping and hand–eye coordination, receiving convergent visual, somatosensory, and motor-related inputs. Neurons in hIP2 exhibit tuning to object features and spatial locations relevant for action planning, and the region participates in the dorsal visual stream circuitry that supports goal-directed behavior and spatial working memory. There is no direct Wikipedia article for hIP2; a related structure is the Intraparietal sulcus.
The bilateral GM Anterior intra-parietal sulcus hIP2 R region in the Juelich maxprob thr25 1mm atlas corresponds to a higher-order parietal area implicated in visuomotor integration, attention, number processing, and tool use, and genetic associations identified in large-scale imaging-genetics and GWAS studies generally involve broader intraparietal or inferior parietal territories encompassing this field rather than hIP2 specifically. Variants affecting parietal cortical thickness and surface area—often in or near neurodevelopmental and synaptic genes such as CADM2, HMGA2, MIR137, and multiple loci identified in ENIGMA and UK Biobank cortical GWAS—have been linked to structural variation in parietal association cortex, including regions overlapping the anterior intraparietal sulcus. Functionally, polygenic risk for neurodevelopmental and psychiatric disorders (autism spectrum disorder, ADHD, schizophrenia, and major depression) and for cognitive traits (general intelligence, educational attainment, working memory) shows robust associations with parietal activation and connectivity patterns, and imaging-genetics work indicates that atypical intraparietal sulcus structure and function mediates part of the effect of these risk variants on cognition and behavior. In addition, GWAS of hand preference, motor coordination, and mathematical ability have identified loci whose effects converge on parietal sensorimotor and numerical networks involving the anterior intraparietal sulcus, while risk variants for Alzheimer’s disease and other dementias show downstream associations with atrophy patterns that include inferior and intraparietal regions; however, to date, no single gene or locus has been uniquely and reproducibly tied to the hIP2 subregion independent of the broader intraparietal parietal cortex.
Overview generated by GPT-4o (2026).
Region ID: 4
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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