The bilateral GM Inferior parietal lobule PFm R, as defined in the Juelich maxprob thr25 1mm atlas, corresponds to a cytoarchitectonic subregion within the supramarginal/posterior inferior parietal cortex of the right hemisphere, involved in multimodal integration of visual, somatosensory, and auditory information. This area contributes to higher-order functions including spatial attention, action observation, sensorimotor integration, and aspects of language processing such as phonological and semantic mapping, often in interaction with frontal and temporal association cortices. It participates in large-scale networks implicated in social cognition and body-related representations, reflecting its role in linking sensory inputs to motor programs and cognitive operations. There is no direct Wikipedia article for PFm; a closely related structure is the inferior parietal lobule: Inferior parietal lobule.
Genetic associations specifically tied to the bilateral GM Inferior parietal lobule PFm R (Juelich maxprob thr25 1 mm Atlas) are not well characterized at fine-grained cytoarchitectonic resolution, but broader genetic and imaging-genetic studies implicate the inferior parietal lobule (IPL) and adjacent parietal association cortex—within which PFm lies—in multiple traits and disorders. Large-scale GWAS of cortical surface area and thickness have identified common variants (e.g., in genes related to synaptic development and neuronal migration such as CENPW, DAAM2, and variants near FOXP2 and CNTNAP2) that influence parietal association cortex morphology, including inferior parietal regions, and these structural differences often overlap with hubs of language, semantic processing, attention, and social cognition. The IPL shows heritable variation in volume and connectivity and has been repeatedly implicated in imaging-genetics studies of schizophrenia, autism spectrum disorder, ADHD, and Alzheimer’s disease, where risk alleles in genes like APOE, CLU, and CR1 are associated with altered parietal atrophy patterns and connectivity in default-mode and frontoparietal networks. Polygenic risk scores for psychiatric and cognitive traits (e.g., educational attainment, general cognitive ability) correlate with IPL thickness and functional activation patterns in tasks involving working memory, attention reorienting, and theory of mind, suggesting that distributed genetic influences on cortical development and synaptic plasticity shape PFm-related circuits. However, current GWAS and neuroimaging-genetics datasets typically do not resolve associations at the level of PFm subfields defined in the Juelich atlas, so evidence for direct gene–PFm R links remains indirect, inferred from studies of the broader inferior parietal lobule and temporoparietal junction rather than this specific microstructural region.
Overview generated by GPT-4o (2026).
Region ID: 32
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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