The bilateral GM Inferior parietal lobule PGp L, as defined in the Juelich maxprob thr25 1mm atlas, corresponds to a cytoarchitectonic subregion of the inferior parietal lobule located in the posterior part of the parietal cortex, bordering visual and higher-order association areas. This region is implicated in multimodal integration of visual, auditory, and somatosensory information, and contributes to functions such as spatial attention, visuomotor coordination, and aspects of language and semantic processing. PGp belongs to the inferior parietal lobule, which forms part of the posterior parietal cortex and participates in large-scale networks involved in attention, default-mode processing, and social-cognitive functions. There is no direct Wikipedia article for PGp; a related structure is the Inferior parietal lobule.
The bilateral GM Inferior parietal lobule PGp L (posterior angular gyrus/PGp sector) from the Juelich maxprob atlas is not yet the focus of region-specific GWAS, but a convergent genetic–neuroanatomical picture has emerged for the inferior parietal/angle gyrus territory more broadly: large-scale imaging–genetics studies (e.g., ENIGMA and UK Biobank) show that cortical thickness, surface area, and volume in inferior parietal/temporo‑parietal regions are heritable and associated with common variants in genes involved in neurodevelopment, synaptic plasticity, and axon guidance (including but not limited to pathways containing genes such as BDNF, HMGA2, and multiple loci on chromosomes 3, 6, and 17), and these parietal measures partially mediate genetic risk for cognitive performance and educational attainment. Polygenic signals for general intelligence, reading and language skills, working memory, and numerical ability consistently implicate inferior parietal/PGp territory as a key structural and functional hub, aligning with its role in semantic processing, default-mode activity, and multimodal integration. GWAS and imaging–genetics work in neuropsychiatric disorders—particularly schizophrenia, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder—highlight altered structure or connectivity of inferior parietal/angular regions as downstream correlates of disorder risk loci, with some overlap in synaptic and neurodevelopmental gene sets identified in both case–control GWAS and brain-morphometry GWAS. Additionally, genetic variants associated with Alzheimer’s disease, frontotemporal degeneration, and broader neurodegenerative polygenic risk scores show effects on posterior parietal/PGp atrophy patterns, consistent with the region’s involvement in default-mode and association networks targeted early in these disorders.
Overview generated by GPT-4o (2026).
Region ID: 39
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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