The bilateral GM Inferior parietal lobule PGp R from the Juelich maxprob thr25 1mm Atlas corresponds to a posterior subdivision of the inferior parietal lobule (IPL), typically associated with higher-order multimodal integration. This region participates in combining visual, auditory, and somatosensory information and is implicated in processes such as spatial attention, body representation, language-related functions (particularly semantic and phonological processing), and aspects of social cognition and theory of mind. Functionally, PGp overlaps with parts of the angular gyrus and neighboring IPL territories, contributing to the default mode and frontoparietal control networks. Through extensive connectivity with frontal, temporal, and occipital cortices, it supports flexible re-mapping of sensory input into abstract representations relevant for reasoning, memory retrieval, and goal-directed behavior. There is no direct Wikipedia article for PGp; a closely related structure is the Inferior parietal lobule.
The bilateral inferior parietal lobule, particularly the posterior angular gyrus subregion corresponding to PGp in the Juelich maxprob thr25 1 mm atlas, has been implicated in multiple genetic and GWAS-based associations through its roles in language, numerical cognition, default mode network function, and multimodal integration. Imaging–genetics and large-scale neuroimaging GWAS (e.g., ENIGMA and UK Biobank–based studies) have linked interindividual variability in cortical thickness, surface area, and volume of inferior parietal areas to common variants in genes involved in neurodevelopment, synaptic plasticity, and axon guidance (including loci near genes such as HMGA2, MAPT, and others associated with global and regional cortical morphology). Genetic overlap has been reported between structural measures in inferior parietal/parietal association cortex and risk for schizophrenia, major depressive disorder, autism spectrum disorder, and attention-deficit/hyperactivity disorder, consistent with observed case–control differences in this region. GWAS of cognitive traits (general intelligence, educational attainment, reading ability, and mathematical performance) and resting-state functional connectivity have also identified polygenic influences that partially converge on inferior parietal and angular gyrus networks, suggesting that variation in this region reflects pleiotropic genetic effects on higher-order association cortex. Although precise locus- and gene-level annotations specifically and exclusively tied to PGp R are limited, converging genetic and imaging-genetic evidence supports a role for this parietal association region as a structural and functional node influenced by polygenic risk for neuropsychiatric disorders and cognitive traits.
Overview generated by GPT-4o (2026).
Region ID: 40
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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