The bilateral GM Primary somatosensory cortex BA2 L, as defined in the Juelich maxprob thr25 1 mm atlas, corresponds to the left-hemispheric portion of Brodmann area 2 within the primary somatosensory cortex, located in the posterior part of the postcentral gyrus of the parietal lobe. This region integrates somatosensory input from thalamocortical and corticocortical pathways and is particularly involved in higher-order processing of tactile and proprioceptive information, including complex features such as object shape, size, and texture (stereognosis), as well as aspects of sensorimotor coordination. Neurons in BA2 receive convergent inputs from more primary somatosensory fields (e.g., BA3 and BA1) and contribute to constructing an integrated representation of the body and external objects, supporting fine manual dexterity and perception of complex somatic stimuli. There is no direct Wikipedia article for “Primary somatosensory cortex BA2 L,” but it is part of Brodmann area 2.
The bilateral GM Primary somatosensory cortex BA2 (left hemisphere) from the Juelich maxprob thr25 1 mm atlas has been implicated indirectly in genetic studies through imaging-genetics and GWAS of cortical structure, pain, and neurodevelopmental traits rather than via region-specific candidate genes. Large-scale cortical thickness and surface area GWAS (e.g., ENIGMA, UK Biobank) have identified common variants in pathways related to neuronal development, synaptic function, and myelination (such as genes in Wnt, MAPK, and glutamatergic signaling) that influence somatosensory cortical morphology, including parietal regions encompassing BA2. Polygenic risk for schizophrenia, autism spectrum disorder, ADHD, and major depressive disorder has been associated with subtle structural and functional alterations in somatosensory and parietal cortices, suggesting pleiotropic genetic influences on sensory integration and higher-order somatosensory processing. Pain-related GWAS, particularly for chronic widespread pain, neuropathic pain, and migraine, consistently implicate networks including the primary somatosensory cortex, and genetic variants affecting nociceptive processing, neuroinflammation, and cortical excitability (e.g., voltage-gated ion channels, neurotransmitter receptors) are thought to modulate activity and plasticity within BA2. In addition, genes linked to tactile sensitivity, motor-sensory integration, and body-schema representation (for example, loci implicated in developmental coordination and specific learning disorders) show associations with structural or functional metrics in parietal somatosensory areas overlapping BA2, although no single gene or variant has been uniquely and reproducibly tied specifically and exclusively to the BA2 L region in current atlased-based genetic literature.
Overview generated by GPT-4o (2026).
Region ID: 53
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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