The bilateral GM Superior parietal lobule 5Ci R, as defined in the Juelich maxprob thr25 1 mm atlas, corresponds to a cytoarchitectonic subregion of Brodmann area 5 located in the superior parietal lobule along the medial wall of the parietal cortex, typically in the right hemisphere for the “R” designation. This region is part of the posterior parietal cortex and is implicated in higher-order somatosensory integration, visuomotor coordination, and the transformation of sensory input into motor commands, particularly for reaching and grasping movements and spatial attention. It receives convergent input from primary and secondary somatosensory areas and projects to premotor and motor regions, supporting sensorimotor transformations and body schema representation. There is no direct Wikipedia article for 5Ci; a related structure is the Superior parietal lobule.
The bilateral GM Superior parietal lobule 5Ci (right hemisphere) in the Juelich maxprob thr25 1mm atlas corresponds to a cytoarchitectonic subregion of the superior parietal lobule involved in visuospatial integration, attention, and sensorimotor control, and genetic associations for this area are mostly inferred from broader parietal or superior parietal measures rather than 5Ci-specific studies. Large neuroimaging GWAS, such as those from ENIGMA and UK Biobank, have identified multiple common variants (e.g., in genes related to neurodevelopment, synaptic function, and axonal guidance such as DPYSL3, CADM2, and variants near MEF2C and HMGA2) that influence cortical thickness, surface area, or volume in parietal regions, with some loci showing shared genetic architecture with general cognitive ability, educational attainment, and working memory performance. Superior parietal morphology and activation, including regions overlapping 5Ci, have been genetically linked to attentional control networks, and polygenic risk for attention-deficit/hyperactivity disorder and schizophrenia shows associations with structural and functional measures in parietal cortices, although findings are often distributed and not specific to 5Ci. GWAS of chronic pain, somatosensory traits, and motor coordination have implicated parietal areas within dorsal sensorimotor networks, suggesting that genetic variants influencing parietal structure and connectivity may contribute to susceptibility to disorders of perception and motor planning. Overall, current evidence points to a polygenic influence on superior parietal lobule structure and function that is shared across cognition, neurodevelopmental and psychiatric risk, and sensorimotor traits, but direct, high-resolution genetic association studies targeting the 5Ci subregion itself remain limited, and most findings derive from atlas-level parietal measures rather than Juelich 5Ci-specific GWAS.
Overview generated by GPT-4o (2026).
Region ID: 68
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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