The bilateral GM Superior parietal lobule area 5L (right) in the Juelich maxprob thr25 1mm Atlas corresponds to a cytoarchitectonically defined subdivision of Brodmann area 5 within the superior parietal lobule, located on the dorsal aspect of the parietal lobe, posterior to the primary somatosensory cortex (areas 3, 1, 2) and anterior to areas 7 and other posterior parietal regions. This region is implicated in higher-order somatosensory processing, including integration of tactile, proprioceptive, and visuospatial information, and contributes to sensorimotor coordination, body schema representation, and visually guided reaching and grasping. Neurons in this area receive convergent input from primary and secondary somatosensory cortices and premotor regions, supporting transformations from sensory to motor coordinates during goal-directed actions and spatial attention. There is no direct Wikipedia article for “area 5L”; a related structure entry is the Superior parietal lobule.
The bilateral GM Superior parietal lobule (SPL; Juelich maxprob thr25 1mm, region 5L/R) has been implicated in several genetic and GWAS-based associations through its roles in visuospatial integration, attention, working memory, and sensorimotor coordination. Twin and heritability studies show substantial genetic influence on SPL cortical thickness and surface area, with common variation in genes affecting neurodevelopment (e.g., BDNF, NRG1, and synaptic plasticity–related loci) contributing to structural variability. Large-scale brain imaging GWAS (e.g., ENIGMA and UK Biobank–based studies) have identified loci in or near genes such as HMGA2, IGF1, and other growth- and neurogenesis-related genes associated with parietal lobe surface area and thickness, which include superior parietal regions. Functionally, polygenic risk scores for schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder have been linked to altered structure or activation of SPL or adjacent superior parietal areas, consistent with the region’s involvement in higher-order cognition and sensory integration. GWAS of cognitive ability and educational attainment have also shown that genetic variants associated with these traits correlate with superior parietal morphology and activation patterns, aligning with SPL’s contribution to spatial reasoning, working memory, and attention networks. While no single gene is uniquely or specifically tied to the 5L/R SPL region in current atlases, convergent genetic evidence from imaging-genetics, neurodevelopmental, and psychiatric GWAS supports a robust, polygenic influence on its structure and function across cognitive and neuropsychiatric traits.
Overview generated by GPT-4o (2026).
Region ID: 70
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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