The bilateral GM Superior parietal lobule 5M R, as defined in the Juelich maxprob thr25 1mm atlas, corresponds to a cytoarchitectonically characterized subregion (area 5M) of the superior parietal lobule located on the medial aspect of the parietal cortex, posterior to the primary somatosensory areas. This region is implicated in higher-order somatosensory processing, integration of proprioceptive and tactile information, and sensorimotor coordination involved in the guidance of limb movements and spatial orientation. Neurons in area 5M contribute to internal representations of body position and movement in space, supporting functions such as reaching, grasping, and postural control, and are interconnected with premotor and motor cortical areas as well as other parietal regions. There is no direct Wikipedia article for “Superior parietal lobule 5M”; a related and encompassing structure is the Superior parietal lobule.
The bilateral GM Superior parietal lobule 5M (right hemisphere) from the Juelich maxprob thr25 1mm atlas lies within the superior parietal lobule (SPL), a multimodal association region implicated in visuospatial attention, sensorimotor integration, and higher-order cognitive control, and genetic associations for this area are typically inferred from broader SPL or parietal cortical measures rather than 5M-specific GWAS. Large-scale brain imaging genetics consortia (e.g., ENIGMA, UK Biobank) have identified common variants in genes involved in neurodevelopment, synaptic plasticity, and axon guidance—such as BDNF, NRG1, ROBO1/2, and genes influencing cortical surface area and thickness (e.g., variants near HMGA2, RSPO3, and other Wnt/Hedgehog pathway–related loci)—that show effects on parietal cortical morphology, including the superior parietal lobule. Parietal regions encompassing 5M have appeared in imaging–genetics studies of attention-deficit/hyperactivity disorder, schizophrenia, and autism spectrum conditions, where risk variants in large-effect neurodevelopmental genes (e.g., 22q11.2 CNVs, genes affecting glutamatergic signaling and synaptic scaffolding) have been associated with altered parietal structure or activation patterns. GWAS of cognitive traits (general intelligence, working memory, educational attainment) and visuospatial skills have identified polygenic architectures that, in imaging follow-ups, partly manifest through structural and functional variation in parietal association cortex, including SPL territory overlapping 5M. Additionally, parietal atrophy or connectivity alterations with partial genetic contributions has been reported in neurodegenerative and cerebrovascular conditions (e.g., Alzheimer’s disease, posterior cortical atrophy), in which risk alleles such as APOE ε4 and other AD GWAS loci (e.g., near CLU, PICALM, CR1) modulate vulnerability of parietal regions. However, no GWAS or candidate-gene study to date has isolated the 5M subfield itself as a primary locus of genetic association, so current knowledge reflects broader parietal or superior parietal lobule genetics rather than region-specific findings for GM Superior parietal lobule 5M R.
Overview generated by GPT-4o (2026).
Region ID: 72
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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