The bilateral WM Cingulum R in the Juelich maxprob thr25 1mm atlas refers to the right-sided portion of the cingulum white matter tract, a major association bundle running within the cingulate gyrus and connecting medial frontal, parietal, and temporal cortices, including components of the limbic system such as the cingulate cortex and hippocampal formation. This tract supports integration of cognitive, emotional, and memory-related information by linking prefrontal regions involved in executive control with posterior cingulate and parahippocampal areas implicated in autobiographical memory and visuospatial processing. Structurally, it follows the curvature of the corpus callosum and extends into the parahippocampal region, contributing to large-scale networks such as the default mode network; damage or microstructural alterations in the cingulum have been associated with neuropsychiatric and neurodegenerative conditions. There is no direct Wikipedia article for “bilateral WM Cingulum R”; a related structure is the Cingulum (brain).
The bilateral cingulum bundle in the Juelich maxprob thr25 1mm atlas (WM Cingulum R) has been repeatedly implicated in imaging-genetics and GWAS work examining white-matter microstructure, although associations are typically reported for general “cingulum” rather than that exact parcellation. Large diffusion MRI GWAS consortia (e.g., ENIGMA, UK Biobank–based studies) have identified common variants influencing fractional anisotropy and mean diffusivity in the cingulum, with robust hits in and near genes involved in axon guidance, myelination, and neuronal development (such as ROBO1/ROBO2, CNTN4, NCAM1, and genes within major histocompatibility complex and oligodendrocyte-related pathways). Polygenic risk for schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum conditions has been associated with altered cingulum integrity, and specific loci associated with psychiatric risk (e.g., near CACNA1C, ZNF804A, and MIR137) have been linked to white-matter changes that include the cingulum in multivariate or region-of-interest analyses. Additionally, GWAS of cognitive performance, educational attainment, and neuroticism have identified overlapping genetic architectures with cingulum microstructure, suggesting that variants influencing this tract also contribute to higher-order cognitive and affective traits. Evidence from Alzheimer’s disease and other neurodegenerative GWAS indicates that risk variants in genes like APOE and CLU are related to white-matter abnormalities involving the cingulum, consistent with its role in limbic and default-mode networks, though effects are often modest and distributed rather than specific to the right cingulum bundle alone.
Overview generated by GPT-4o (2026).
Region ID: 96
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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