The bilateral GM Inferior parietal lobule PFm R, as defined in the Juelich maxprob thr25 2mm atlas, corresponds to a cytoarchitectonically characterized subregion (PFm) of the inferior parietal lobule (IPL) in the right hemisphere, with homologous tissue present bilaterally. This region lies within the posterior parietal cortex and is implicated in higher-order multimodal integration, including visuospatial processing, attention reorientation, sensorimotor transformation, and aspects of social cognition such as perspective-taking and action understanding. PFm participates in fronto-parietal networks that support goal-directed behavior and may contribute to language-related processes through integration of auditory, visual, and somatosensory information. There is no direct Wikipedia article for PFm; a related structure is the Inferior parietal lobule.
The bilateral Inferior parietal lobule PFm region, as defined in the Juelich maxprob thr25 2 mm atlas, has been implicated in genetic studies primarily through its role in higher-order association cortex, where polygenic influences on cortical thickness, surface area, and gyrification have been repeatedly demonstrated in large-scale GWAS of brain morphology. Variants in genes involved in synaptic plasticity, neurodevelopment, and axon guidance (such as BDNF, CNTNAP2, and common schizophrenia and autism spectrum disorder risk loci) have been associated with structural and functional alterations in inferior parietal regions, including PFm, particularly in relation to language, social cognition, working memory, and attentional control networks. Imaging-genetics studies link polygenic risk scores for schizophrenia, major depressive disorder, ADHD, and Alzheimer’s disease to volumetric and connectivity changes in inferior parietal lobule subregions, and several GWAS of cognitive traits (general intelligence, educational attainment, reading and math ability) report that genetic variants influencing parietal association cortex contribute to individual differences in these abilities. Although most findings are at the level of broader inferior parietal or parietal association cortex rather than PFm specifically, convergent evidence indicates that this PFm subregion participates in genetically influenced large-scale frontoparietal and default-mode networks, with its structure and function modulated by common variants that confer risk for neurodevelopmental and psychiatric disorders and shape complex cognitive traits.
Overview generated by GPT-4o (2026).
Region ID: 32
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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