The bilateral GM Inferior parietal lobule PFop L, as defined in the Juelich maxprob thr25 2mm atlas, corresponds to a left-hemispheric cytoarchitectonic subdivision of the inferior parietal lobule (IPL) located in the posterior parietal cortex, at the junction of the supramarginal and angular gyri near the parietal–temporal boundary. This region is implicated in multimodal integration of visual, auditory, and somatosensory information, supporting higher-order functions such as language processing (particularly phonological and semantic aspects), praxis, attention reorienting, and aspects of social cognition and theory of mind. PFop L participates in networks involving the superior temporal, frontal, and premotor cortices and is thought to contribute to left-hemispheric dominance for language and tool-related actions. There is no direct link for PFop specifically; a related structure is the Inferior parietal lobule.
The bilateral GM Inferior parietal lobule PFop L (Juelich maxprob thr25 2mm) lies within the inferior parietal cortex, a heteromodal association area repeatedly implicated in large-scale imaging genetics studies rather than gene–region–specific GWAS. Variants influencing cortical surface area and thickness in inferior parietal and adjacent supramarginal/angular gyri have been identified in several consortia (e.g., ENIGMA, UK Biobank), with common loci including genes involved in synaptic signaling, neurodevelopment, and axon guidance (such as variants near HMGA2, NRXN1, and genes in Wnt and Notch pathways), although these findings are typically reported for broader parietal parcels rather than PFop specifically. Functionally, the inferior parietal lobule is a key node of the frontoparietal and default mode networks, and genetic studies link parietal morphology and connectivity to cognitive traits (general intelligence, working memory, language function), handedness, and educational attainment, with polygenic scores for these traits correlating with structure and activation in inferior parietal regions. Moreover, risk alleles for neurodevelopmental and psychiatric conditions—particularly schizophrenia, ADHD, autism spectrum disorder, and major depression—have been associated with alterations in inferior parietal cortical thickness, surface area, or activation patterns in imaging–genetics frameworks, and parietal atrophy and connectivity changes in Alzheimer’s disease and other dementias show genetic modulation by APOE and other susceptibility loci. However, existing GWAS typically use macro-anatomical or functional parcellations, so genetic associations are attributable to the broader inferior parietal cortex within which PFop L resides, rather than to this cytoarchitectonic subregion in isolation.
Overview generated by GPT-4o (2026).
Region ID: 33
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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