The bilateral GM Inferior parietal lobule PFt R (Juelich maxprob thr25 2mm Atlas) corresponds to a cytoarchitectonically defined subregion within the inferior parietal lobule, associated with higher-order multimodal integration and traditionally linked to the supramarginal/angular gyrus complex. This area is implicated in processes such as sensorimotor integration, spatial attention, action observation, and aspects of language and social cognition, consistent with the broader role of the inferior parietal cortex in integrating visual, somatosensory, and auditory information with motor and cognitive functions. Although there is no direct Wikipedia article specifically for “PFt,” it is part of the Inferior parietal lobule.
The bilateral inferior parietal lobule, including the PFt subregion in the right hemisphere as defined in the Juelich maxprob thr25 2mm atlas, has been implicated in genetic studies primarily through imaging genetics and large-scale GWAS of brain structure and function rather than region-specific candidate gene work. Variants near or within genes involved in synaptic plasticity, neurodevelopment, and axon guidance (such as BDNF, CNTNAP2, and genes within the MHC region) have been associated with parietal cortical thickness, surface area, and activation patterns in attention and language tasks, which often recruit inferior parietal areas including PFt. GWAS of cortical regional measures (e.g., ENIGMA consortium studies) have identified multiple loci associated with parietal lobe morphology that overlap with risk loci for neurodevelopmental and psychiatric conditions, including schizophrenia, ADHD, and autism spectrum disorder, suggesting shared genetic architecture influencing both parietal anatomy and disease risk. Polygenic risk scores for schizophrenia and major depression have been linked to altered parietal activation and connectivity in task-based and resting-state fMRI, with inferior parietal regions frequently implicated in networks for social cognition and default-mode function. Additionally, genetic variants associated with cognitive traits (such as general intelligence, working memory, and educational attainment) show correlations with structural and functional measures of inferior parietal cortex, although specific PFt-focused genetic associations remain limited, and most evidence derives from broader parietal or temporoparietal junction analyses rather than this cytoarchitectonic subfield alone.
Overview generated by GPT-4o (2026).
Region ID: 36
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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