The bilateral GM Lateral geniculate body (LGB) in the Juelich maxprob thr25 2mm Atlas corresponds to a pair of thalamic relay nuclei that form the principal subcortical station in the visual pathway. Located in the posterior thalamus, each LGB receives topographically organized input from retinal ganglion cells via the optic tract and projects primarily to the primary visual cortex (V1, Brodmann area 17) through the optic radiation. The LGB is laminated into magnocellular and parvocellular layers, which differentially process motion, depth, and low-contrast information versus high-acuity color and form, respectively, and is further modulated by feedback from visual cortex and inputs from other brain regions, integrating feedforward and feedback signals to shape visual perception. There is no direct Wikipedia article for this specific atlas-defined region; a closely related and encompassing structure is the Lateral geniculate nucleus.
The lateral geniculate body (lateral geniculate nucleus, LGN) of the thalamus, including the left-sided/bilateral GM lateral geniculate body as defined in the Juelich maxprob thr25 2 mm atlas, has been implicated indirectly in genetic studies primarily through its central role in visual processing and thalamocortical circuitry rather than via many region-specific GWAS hits. Structural and functional measures involving the LGN or closely related thalamic visual pathways have been associated with variants in genes affecting axonal guidance, myelination, and synaptic transmission (for example, in pathways involving NRG1/ERBB signaling, synaptic scaffolding genes, and white-matter–related loci) in large imaging-genetics datasets, though these associations are often reported at the broader “thalamus” or “visual system” level rather than the LGN alone. Disorders with strong genetic components that show LGN involvement include multiple sclerosis, neuromyelitis optica spectrum disorders, and other demyelinating diseases (where HLA and immune-related loci are major GWAS findings), as well as glaucoma and optic neuropathies, in which risk variants in genes such as MYOC, OPTN, and others affecting retinal ganglion cells secondarily influence LGN structure and function. Neurodevelopmental and neuropsychiatric conditions with polygenic architectures, including schizophrenia, autism spectrum disorder, and major depression, show thalamic and visual pathway alterations in imaging genetics, but specific, reproducible SNP-level associations mapped uniquely and directly to the LGN (as a distinct atlas region) remain limited; current evidence mainly reflects polygenic influences on thalamocortical networks that encompass the lateral geniculate body rather than region-exclusive genetic risk.
Overview generated by GPT-4o (2026).
Region ID: 104
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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