The bilateral GM Secondary somatosensory cortex Parietal operculum OP1 R, as defined in the Juelich maxprob thr25 2 mm atlas, corresponds to a cytoarchitectonic subdivision of the human parietal operculum that forms part of the secondary somatosensory cortex (SII). This region lies in the posterior portion of the lateral sulcus overlying the insula and is engaged in higher-order somatosensory processing, including integration of tactile, nociceptive, and proprioceptive information from both sides of the body, as well as contributing to sensorimotor integration, tactile object recognition, and aspects of pain perception. OP1 is strongly interconnected with primary somatosensory cortex, insula, premotor areas, and subcortical structures, supporting multimodal sensory representation and bilateral receptive fields characteristic of SII. There is no direct Wikipedia article on OP1; a related entry is the Parietal operculum.
The bilateral GM Secondary somatosensory cortex Parietal operculum OP1 R, as defined in the Juelich maxprob thr25 2 mm atlas, lies within the posterior parietal operculum and has been indirectly implicated in several genetic and GWAS-based associations through studies of somatosensory, pain, and sensorimotor-related traits rather than through OP1-specific loci. Imaging–genetics and large-scale GWAS of cortical structure and function have linked variants in genes involved in neurodevelopment, synaptic signaling, and myelination (for example, polygenic influences overlapping with MAPT, GRIN2B, and multiple calcium-channel and axon-guidance genes) to interindividual differences in thickness, surface area, and functional activation of parietal opercular and secondary somatosensory regions, including OP1. Parietal opercular S2/OP1 activity and structure show heritable components and have been associated with genetic risk for chronic pain conditions (such as migraine, chronic back pain, and neuropathic pain), somatosensory hypersensitivity and allodynia, and, in some imaging–genetics work, polygenic risk scores for autism spectrum disorder and attention-deficit/hyperactivity disorder, which often involve altered sensory processing; however, these effects are typically distributed and not specific to OP1 alone. In addition, GWAS of resting-state networks and task-based fMRI have identified common variants influencing somatosensory and perisylvian opercular networks comprising OP1, linking this region to broader polygenic architectures for sensorimotor integration, pain modulation, and body-awareness traits, but no single gene or variant has been robustly and uniquely tied to the OP1 R region in isolation.
Overview generated by GPT-4o (2026).
Region ID: 60
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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