The bilateral WM Optic radiation R in the Juelich maxprob thr25 2mm atlas refers to the right-hemispheric portion of the white matter optic radiations, a major fiber pathway conveying visual information from the lateral geniculate nucleus of the thalamus to the primary visual cortex (V1) in the occipital lobe. These fibers form part of the geniculocalcarine tract and include both dorsal and ventral components, with the ventral portion corresponding to Meyer’s loop, which arcs anteriorly into the temporal lobe before turning posteriorly toward the calcarine sulcus. Functionally, the optic radiations transmit retinotopically organized visual signals crucial for conscious visual perception, with damage to the right optic radiation typically producing characteristic left visual field (contralateral) defects such as homonymous hemianopia or quadrantanopia. There is no direct Wikipedia article for “Optic radiation (white matter, right hemisphere)” as a separate entity; a closely related entry describing the same tract is Optic radiation.
The bilateral white-matter optic radiation region (R) from the Juelich maxprob thr25 2 mm atlas, encompassing major geniculocalcarine visual pathways, has been implicated indirectly through GWAS of brain structural connectivity, white-matter microstructure, and visual system traits rather than through many studies targeting this exact parcel. Large diffusion MRI GWAS (e.g., UK Biobank) have associated variants in genes involved in axon guidance, myelination, and neurodevelopment—such as those within pathways related to semaphorins, netrins, and oligodendrocyte function—with inter-individual differences in fractional anisotropy and other diffusion metrics in optic radiations and adjacent posterior white matter. Common variants in genes like APOE, CLU, and other Alzheimer’s disease–risk loci show associations with posterior white-matter integrity that often include or border optic radiation tracts, supporting a role in neurodegenerative white-matter vulnerability. Visual pathway white matter, including optic radiation regions, has also been implicated in polygenic architectures of disorders such as multiple sclerosis, schizophrenia, and major depression via imaging-genetics work linking disease-associated loci to altered microstructural measures in these tracts, though these studies typically report broader posterior thalamic radiations rather than this specific atlas-defined region. Overall, genetic associations point to polygenic influences on development, maintenance, and degeneration of the optic radiations, but precise gene–region mappings for the bilateral WM Optic radiation R parcel remain largely indirect and inferred from broader white-matter and visual-system imaging GWAS.
Overview generated by GPT-4o (2026).
Region ID: 108
Hemisphere: bilateral
Atlas: Juelich maxprob thr25 2mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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