The striato-occipital left white matter tract, as defined in the Pandora-TractSeg Atlas, is a long associative projection pathway connecting the striatum—primarily components of the basal ganglia such as the caudate nucleus and putamen—to posterior occipital cortical regions involved in visual processing. This tract courses through the deep white matter of the hemisphere, integrating subcortical motor, reward, and associative signals from the striatum with higher-order visual and visuospatial processing areas of the occipital lobe, thereby contributing to the modulation of visual perception, attention, and visually guided behavior based on motivational and contextual information. There is no direct Wikipedia article for this tract; a closely related and encompassing structure is the Basal ganglia.
As of 2024, there are no well-established, tract-specific genetic association findings published for the left striato-occipital white matter tract as defined in the Pandora-TractSeg Atlas, and most large diffusion MRI GWAS have focused on broader or differently parcellated tracts (e.g., major association, projection, and callosal pathways) without isolating this particular pathway. Genome-wide studies of diffusion metrics such as fractional anisotropy and mean diffusivity consistently implicate genes and loci involved in axonal growth, myelination, and neurodevelopment (for example, variants near or within genes such as DPYSL5, CNTN4, and others in axon guidance and oligodendrocyte biology), and they show heritable influences on fronto-striatal and occipital connectivity, but these effects are reported at the level of larger tract systems or voxelwise patterns, not the specific striato-occipital tract in this atlas. Similarly, genetic links between white matter microstructure and disorders such as schizophrenia, major depression, ADHD, or neurodegenerative diseases have been described using global or regionally aggregated diffusion measures, but no robust, replicated GWAS or candidate-gene results have yet singled out the left striato-occipital tract from Pandora-TractSeg as a distinct locus of genetic association.
Overview generated by GPT-4o (2026).
Region ID: 44
Hemisphere: left
Atlas: Pandora-TractSeg
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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