The Thalamo-precentral left white matter tract is a projection pathway connecting nuclei of the left thalamus with the precentral gyrus, the primary motor cortex region responsible for voluntary movement initiation and control. This tract carries processed sensory, motor, and integrative signals from thalamic relay and association nuclei to cortical motor areas, supporting functions such as motor planning, execution, and modulation of corticospinal output. As part of the broader thalamocortical system, it contributes to sensorimotor integration, timing, and coordination of movements, and may be implicated in motor deficits when disrupted by lesions, neurodegenerative processes, or developmental abnormalities. There is no direct link for this specific tract; see the related structure Thalamocortical radiations.
As of 2024, there are no tract-specific genetic association studies that isolate the “Thalamo-precentral left” white matter pathway from the Pandora-TractSeg Atlas, and virtually no publications report GWAS findings explicitly under this tract label; genetic results for diffusion MRI measures (e.g., FA, MD) are generally aggregated at the level of broader projection systems, whole-brain white matter, or major tracts such as the corticospinal tract and thalamic radiations rather than this specific connection. Large GWAS of white matter microstructure (e.g., UK Biobank–based studies by Elliott et al., Zhao et al., Smith et al., and others) consistently show that diffusion measures in motor- and thalamus-related projection fibers are moderately heritable and influenced by common variants in genes involved in axon guidance, myelination, and neurodevelopment (for example, loci near genes such as CNTN4/6, NCAM1, MAG, and others), and polygenic overlap has been documented with neuropsychiatric disorders (schizophrenia, bipolar disorder, major depression), cognitive performance, and motor-related traits. However, these findings typically pertain to larger structures like internal capsule fibers, corticospinal tracts, and thalamic radiations as a whole; any inferences about the Thalamo-precentral left tract in the Pandora-TractSeg Atlas are indirect and extrapolated from these broader motor and thalamocortical pathways rather than from direct tract-specific GWAS evidence.
Overview generated by GPT-4o (2026).
Region ID: 64
Hemisphere: left
Atlas: Pandora-TractSeg
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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