The bilateral Inter-Hemispheric Occipital Lobe Lingual Gyrus refers to the medial portions of the lingual gyri in both hemispheres, situated along the calcarine sulcus in the occipital lobe and extending inter-hemispherically across the midline. This region is part of the ventral visual cortex and is implicated in early visual processing, including analysis of complex visual patterns, letters, and word forms, as well as aspects of color and scene perception. It receives primary visual input from the striate and extrastriate cortices and participates in pathways supporting visual recognition and reading. The lingual gyrus is also involved in higher-order integration of visual information with memory and contextual associations via connections to temporal and limbic structures. There is no direct link for “Inter-Hemispheric Occipital Lobe Lingual Gyrus”; a related structure is the Lingual gyrus.
The bilateral inter-hemispheric occipital lingual gyrus, as defined in the Talairach 1 mm atlas, has been implicated in several genetic and genome-wide association studies (GWAS), primarily via its roles in visual processing, reading, and higher-order cognitive and affective functions. Polygenic influences on lingual gyrus structure and function have been reported in large neuroimaging genetics consortia such as ENIGMA and UK Biobank, where common variants in genes related to neurodevelopment (e.g., MAPT, APOE, and other loci affecting cortical thickness and surface area) show associations with occipital and ventral visual cortices, including the lingual gyrus. In psychiatric and neurological GWAS, altered lingual gyrus volume or activation has been observed in schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorder, and Alzheimer’s disease, often in relation to polygenic risk scores for these conditions. Language- and reading-related traits, such as developmental dyslexia and reading ability, have also linked variants in genes like DCDC2, KIAA0319, and FOXP2 to functional and structural differences in posterior occipito-temporal regions that encompass or border the lingual gyrus. Additionally, GWAS of brain imaging phenotypes have identified associations between visual cortical regions including the lingual gyrus and loci involved in synaptic signaling, myelination, and axonal guidance, supporting a broadly polygenic architecture in which numerous small-effect variants collectively influence the development and maintenance of this region.
Overview generated by GPT-4o (2026).
Region ID: 243
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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