The bilateral Left Cerebrum.Frontal Lobe.Cingulate Gyrus.Gray Matter.Brodmann area 6 corresponds to premotor and supplementary motor cortex located along the anterior portion of the cingulate gyrus within the frontal lobe, forming part of the medial premotor network. This agranular cortical region participates in the planning, preparation, and sequencing of voluntary movements, particularly those involving internally generated actions, complex motor routines, and the integration of motivational and cognitive signals into motor output. It is heavily interconnected with primary motor cortex, basal ganglia, and prefrontal regions, and contributes to motor attention, response selection, and the regulation of motor behavior under changing task demands. There is no direct link for this exact Talairach label; a closely related structure is Brodmann area 6.
The bilateral Left Cerebrum.Frontal Lobe.Cingulate Gyrus.Gray Matter.Brodmann area 6 (premotor/supplementary motor cingulate territory) has been implicated in genetic studies of motor control, cognitive control, and affective regulation, although most GWAS map to broader cingulate or frontal cortical measures rather than BA6 specifically. GWAS of cortical thickness and surface area frequently identify loci near genes involved in neuronal development and synaptic function (e.g., MAPT, CNTNAP2, FOXP2, and other neurodevelopmental genes) that show associations with cingulate and medial frontal morphology overlapping BA6. Variants in genes related to glutamatergic signaling and neuroplasticity (such as GRIN2B and BDNF) have been linked to structural and functional variation in medial frontal and cingulate motor areas, which participate in action selection and performance monitoring. In psychiatric GWAS, risk alleles for major depressive disorder, schizophrenia, obsessive–compulsive disorder, ADHD, and autism spectrum disorder have been associated with altered activation or gray matter volume in dorsal anterior/mid-cingulate regions that encompass or border BA6, consistent with this area’s role in cognitive control, error processing, and motivated behavior. Large-scale imaging–genetics studies also connect polygenic scores for traits such as general cognitive ability, risk-taking, and neuroticism with microstructural and functional differences in medial frontal and cingulate motor networks, suggesting that BA6 lies within a genetically influenced circuit integrating motor planning with higher-order affective and executive processes.
Overview generated by GPT-4o (2026).
Region ID: 1010
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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