The bilateral Left Cerebrum.Frontal Lobe.Cingulate Gyrus.White Matter corresponds to the intrahemispheric white matter tracts coursing beneath the cingulate gyrus within the medial frontal lobe, primarily comprising fibers of the cingulum bundle that interconnect frontal, parietal, and limbic cortices. These fibers facilitate communication between the anterior cingulate cortex, medial prefrontal regions, and posterior cingulate/retrosplenial areas, supporting functions such as attention, emotion regulation, motivation, and aspects of cognitive control. As part of the limbic white matter system, this region plays a key integrative role in linking higher-order frontal processes with limbic networks involved in affect, autonomic regulation, and memory. There is no direct Wikipedia article for the white matter of the cingulate gyrus; a related structure is the Cingulate gyrus.
The bilateral left cerebrum frontal lobe cingulate gyrus white matter corresponds largely to the cingulum bundle connecting medial frontal, cingulate, and limbic regions, and genetic associations typically emerge from imaging–genetics and GWAS of white-matter microstructure (often via diffusion MRI). Heritability of cingulum fractional anisotropy and related measures is consistently high (often >40–60%), with implicated loci including variants near or within genes involved in axonal growth, myelination, and synaptic function (for example, NTRK3, BDNF, and various cell-adhesion and oligodendrocyte-related genes) in large consortia such as ENIGMA and UK Biobank. Polygenic risk for major depressive disorder, schizophrenia, and bipolar disorder has been linked to altered cingulate/cingulum white-matter integrity, and specific risk variants for schizophrenia (e.g., in CACNA1C and ZNF804A) and major depression (e.g., near SLC6A15) have been associated with microstructural changes in this tract or neighboring medial frontal white matter. GWAS of traits such as neuroticism, anxiety, attention-deficit/hyperactivity disorder, and cognitive performance have also identified overlapping genetic architectures with cingulate white-matter metrics, implicating shared polygenic influences rather than single, region-specific genes. Additionally, Alzheimer’s disease and other neurodegenerative risk alleles (for instance, APOE ε4 and variants near CLU and PICALM) show associations with early cingulum and cingulate white-matter disruption, aligning with this tract’s role in default-mode and memory-related networks.
Overview generated by GPT-4o (2026).
Region ID: 1001
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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