The bilateral Left Cerebrum.Frontal Lobe.Medial Frontal Gyrus.Gray Matter.Brodmann area 32 corresponds primarily to the dorsal portion of the anterior cingulate/medial prefrontal cortex, situated on the medial surface of the frontal lobe just superior to the corpus callosum. This agranular cortex is involved in higher-order cognitive and affective functions, including conflict monitoring, decision-making under uncertainty, error detection, attentional control, and regulation of emotional responses. It forms part of large-scale networks linking prefrontal, limbic, and motor regions, integrating motivational and emotional information with goal-directed behavior. In functional imaging studies, activity in this area is frequently associated with tasks requiring cognitive control, evaluation of action outcomes, and modulation of autonomic responses. No direct link exists for “Brodmann area 32” as a standalone article; a closely related structure is the Anterior cingulate cortex.
The medial frontal gyrus, Brodmann area 32 (part of the dorsal anterior cingulate/medial prefrontal cortex in the Talairach 1 mm atlas), shows convergent genetic associations from GWAS and imaging‑genetics studies with psychiatric, cognitive, and pain-related traits. Variants in COMT (e.g., Val158Met), MAOA, and serotonin transporter genes have long been linked to alterations in medial prefrontal/anterior cingulate structure and function in relation to emotion regulation, anxiety, and stress reactivity, while large ENIGMA and UK Biobank analyses have identified common SNPs in genes involved in neurodevelopment (e.g., MIR137, HMGA2, IGF1, and multiple loci on chromosomes 3, 8, and 12) that influence cortical thickness and surface area in medial prefrontal/anterior cingulate regions that overlap BA32. Polygenic risk for major depressive disorder, schizophrenia, bipolar disorder, and ADHD correlates with gray‑matter volume or cortical thickness changes in this area, and disorder‑specific risk loci (such as those near CACNA1C, DRD2, GRIN2A, and immune‑related genes in the MHC region) have been associated with altered activation or structural differences in BA32 during cognitive control and emotion tasks. GWAS of pain sensitivity, neuroticism, and subjective well‑being also show that polygenic scores for these traits predict anatomical and functional variation in medial frontal/BA32 regions, implicating genes in synaptic plasticity, glutamatergic signaling, and stress‑response pathways. Overall, genetic influences on this region appear highly polygenic and pleiotropic, linking BA32 to vulnerability across mood, psychotic, anxiety, and pain phenotypes through effects on cortical development, excitatory–inhibitory balance, and fronto‑limbic network function.
Overview generated by GPT-4o (2026).
Region ID: 610
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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