The bilateral Left Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 10 corresponds to the anterior portion of the prefrontal cortex, often termed the frontopolar cortex, situated at the most rostral part of the frontal lobe along the middle frontal gyrus. This region is characterized by granular cortex with dense reciprocal connections to other prefrontal, limbic, and association areas, and is implicated in higher-order executive functions including prospective memory, multitasking, complex decision-making, social cognition, and integration of internal goals with external stimuli. Brodmann area 10 plays a role in the coordination of concurrent mental tasks, abstract reasoning, and evaluation of future consequences, and is considered part of the broader network supporting cognitive control and metacognitive processes. There is no direct link for this exact Talairach label; a related structure is Brodmann area 10.
Brodmann area 10 (BA10) in the bilateral middle frontal gyrus, a key prefrontal region implicated in higher-order cognition and social-emotional regulation, shows convergent genetic associations across GWAS and imaging–genetics studies, although most findings are spatially broader than the Talairach 1 mm parcellation. Variants in genes related to synaptic function and neurodevelopment—such as CACNA1C, DRD2, GRM3, COMT, and ZNF804A—have repeatedly been associated with structural and functional alterations in dorsomedial and frontopolar prefrontal cortex encompassing BA10, especially in schizophrenia, bipolar disorder, and major depressive disorder. Large-scale ENIGMA and UK Biobank imaging-GWAS consortia have identified common variants (e.g., in genes near HMGA2, IGF1, and other neurodevelopmental loci) associated with global and regional cortical thickness and surface area in anterior prefrontal regions overlapping BA10, implicating pathways involving neuronal proliferation, cortical patterning, and synaptic plasticity. Risk loci for autism spectrum disorder, ADHD, and externalizing traits have also been linked to altered connectivity and gray-matter measures in medial and lateral BA10, consistent with its role in executive function and social cognition. Additionally, polygenic risk scores for schizophrenia, major depression, and cognitive ability correlate with morphometric variation in BA10 and adjacent prefrontal territories, suggesting that common polygenic architecture contributes to individual differences in this region’s gray matter and to vulnerability for psychiatric and cognitive phenotypes.
Overview generated by GPT-4o (2026).
Region ID: 410
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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