The bilateral Left Cerebrum.Frontal Lobe.Middle Frontal Gyrus.Gray Matter.Brodmann area 6 corresponds primarily to the premotor cortex and supplementary motor areas located anterior to the primary motor cortex on the lateral and medial surfaces of the frontal lobe. This agranular cortical region is involved in planning, sequencing, and preparing voluntary movements, integrating sensory and motor information to select appropriate motor programs, and contributing to motor learning and the control of proximal and axial musculature. Activity in Brodmann area 6 is associated with externally guided movements, motor imagery, and aspects of higher-order motor cognition, including the organization of complex, goal-directed actions. Brodmann area 6
The bilateral left middle frontal gyrus (Brodmann area 6), a premotor/supplementary motor–adjacent region in the frontal lobe, shows genetic associations primarily through imaging–genetics and GWAS of cortical morphology and related neuropsychiatric traits. Large-scale consortia such as ENIGMA and UK Biobank have identified common variants (e.g., in genes influencing neurodevelopment, synaptic function, and myelination) associated with cortical thickness, surface area, and gray matter volume in medial and lateral premotor/middle frontal regions, though these effects are typically reported at lobar or broader parcellation levels rather than Talairach BA6 specifically. Polygenic scores for schizophrenia, bipolar disorder, major depressive disorder, and ADHD are associated with structural and functional variation in adjacent and overlapping middle frontal territories, and rare CNVs implicated in neurodevelopmental disorders often show downstream effects on BA6-adjacent networks involved in motor planning and cognitive control. Functional GWAS-based annotation (e.g., using eQTL and chromatin data) frequently implicates genes regulating early corticogenesis and frontal projection neuron development in loci associated with frontal lobe measures, suggesting that BA6 morphometry reflects partly heritable variation in pathways governing cortical patterning and synaptic organization, although no single gene–region association is uniquely and consistently tied to the Talairach-defined left middle frontal gyrus BA6 at 1 mm resolution.
Overview generated by GPT-4o (2026).
Region ID: 1023
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).