Bilateral Left Cerebrum.Frontal Lobe.Orbital Gyrus.Gray Matter.Brodmann area 11 corresponds to the left orbitofrontal cortex region classified as Brodmann area 11, a portion of prefrontal cortex situated on the ventral surface of the frontal lobe above the orbits of the eyes. This area is implicated in higher-order cognitive and affective processes, including the evaluation of reward and punishment, decision-making under uncertainty, emotional and social behavior regulation, and the integration of sensory and visceral information to guide goal-directed actions. Structurally, it comprises granular prefrontal gray matter interconnected with limbic regions such as the amygdala and hippocampus, as well as other prefrontal areas, supporting its role in value representation, flexible behavioral adaptation, and modulation of autonomic responses. There is no direct Wikipedia article for this exact Talairach-defined region; a closely related structure is the orbitofrontal cortex: Orbitofrontal cortex.
Brodmann area 11 in the orbital gyrus of the left frontal lobe (orbitofrontal cortex, OFC) is frequently implicated in imaging-genetics and GWAS-based neuroimaging studies as part of broader frontal and prefrontal cortical measures rather than as an isolated Talairach-defined parcel, with genetic effects often shared across bilateral OFC. Variants in genes involved in synaptic function and neurodevelopment—such as BDNF, COMT, SLC6A4, and DRD2—have been associated with structural or functional differences in OFC-related regions, influencing gray matter volume, cortical thickness, or activation during reward, decision-making, and emotional regulation tasks. Large-scale GWAS of cortical morphology (e.g., ENIGMA, UK Biobank) have identified polygenic influences on frontal/orbitofrontal thickness and surface area, implicating loci related to neurodevelopmental pathways, axon guidance, and cell adhesion, though often without fine-grained parcellation strictly limited to BA11. Genetically influenced alterations in OFC/BA11 structure and function have been linked to psychiatric and behavioral traits, including major depressive disorder, bipolar disorder, schizophrenia, obsessive–compulsive disorder, substance use disorders, impulsivity, and neuroticism; many of these associations arise from convergent evidence where disorder- or trait-associated variants (from GWAS) map onto networks that prominently include the OFC, suggesting that BA11 gray matter represents a convergent node where polygenic risk for affective, compulsive, and reward-related phenotypes manifests in altered orbitofrontal circuitry.
Overview generated by GPT-4o (2026).
Region ID: 102
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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