The bilateral Left Cerebrum.Frontal Lobe.Precentral Gyrus.Gray Matter.Brodmann area 43 corresponds primarily to the subcentral gyrus and opercular region of the inferior precentral and postcentral cortex, often classified within the parietal–opercular “gustatory” or primary taste area. It lies deep to the frontoparietal operculum overlying the insula, at the junction of frontal and parietal lobes near the lateral sulcus. Cytoarchitectonically, Brodmann area 43 exhibits granular sensory cortex features, and functionally it is implicated in gustatory processing, oral somatosensory integration (including tongue, lips, and oral cavity), and coordination of orofacial and swallowing-related motor patterns in concert with adjacent somatomotor and somatosensory regions. There is no direct link for “Brodmann area 43”; a related structure is Gustatory cortex.
Brodmann area 43 in the precentral gyrus, a sensorimotor region near the face and orofacial representation, has relatively sparse direct genetic association data at the fine-grained Talairach-based label level, but broader imaging-genetics and GWAS-based parcellation studies implicate genes involved in cortical thickness, surface area, and motor-speech circuitry that encompass this territory. Large-scale ENIGMA and UK Biobank imaging GWAS have linked variants in genes regulating neurodevelopment, synaptic function, and myelination (for example, MIR137, HMGA2, and multiple 17q and 3p loci) to structural measures of the precentral gyrus and adjacent frontal opercular cortex, which include or border BA43. Polygenic risk for neuropsychiatric disorders such as schizophrenia, bipolar disorder, autism spectrum disorder, and major depressive disorder shows distributed effects on frontal sensorimotor and opercular regions, including precentral areas, while rare monogenic or CNV syndromes affecting genes like FOXP1/FOXP2, CNTNAP2, and other language- and motor-related loci often exhibit structural and functional alterations in perisylvian and precentral speech–motor regions overlapping BA43. In addition, GWAS of traits related to motor coordination, speech production, orofacial movement, and handedness have reported associations in frontal motor and premotor areas which, when mapped with functional-anatomical atlases, partially localize to the inferior precentral gyrus and Brodmann area 43, though current evidence remains indirect and regionally coarse rather than specific to the bilateral Left Cerebrum.Frontal Lobe.Precentral Gyrus.Gray Matter.BA43 label.
Overview generated by GPT-4o (2026).
Region ID: 739
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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