The bilateral Left Cerebrum.Frontal Lobe.Precentral Gyrus.Gray Matter.Brodmann area 6 corresponds predominantly to the premotor cortex and supplementary motor areas located anterior to the primary motor cortex on the precentral gyrus. This agranular frontal field is involved in the planning, preparation, and coordination of voluntary movements, including selection of motor programs, integration of sensory cues for action, and organization of complex, sequential, or bilateral motor acts. Neuronal populations in Brodmann area 6 contribute to motor learning, posture and gait control, and the transformation of intention into motor output, acting as an interface between higher-order associative regions and primary motor execution areas. There is no direct Wikipedia article for this exact composite label; a related structure is Brodmann area 6.
Genetic associations involving the bilateral left cerebrum frontal lobe precentral gyrus gray matter Brodmann area 6 (premotor/supplementary motor cortex) have emerged largely from imaging‑genetics and GWAS of brain structure and neuropsychiatric traits rather than from region‑specific candidate studies. Variants in genes affecting neurodevelopment and synaptic function (for example, CNTNAP2, DISC1, NRG1, and BDNF) have been linked to altered frontal and premotor cortical morphology or activation, particularly in schizophrenia, autism spectrum disorder, and major depression, although these findings are typically reported at the lobe or frontal cluster level rather than uniquely pinpointing BA6. Large-scale GWAS of cortical surface area and thickness (such as ENIGMA and UK Biobank studies) have identified common variants near genes involved in neuronal proliferation and axon guidance (e.g., HMGA2, TBR1, FGFR2, and other neurodevelopmental loci) associated with primary motor and premotor regions, including superior frontal and precentral parcels that encompass BA6. BA6 has also appeared in imaging-genetics work on motor function, handedness, and response inhibition, with polygenic risk scores for ADHD, schizophrenia, and Parkinson’s disease showing associations with altered activation or structure in premotor territories, though these effects are modest and distributed across many frontal regions. Overall, genetic influences on BA6 are polygenic and shared with broader frontal networks, with current evidence tying this area to neurodevelopmental, motor, and psychiatric phenotypes rather than to any single gene or variant uniquely specific to this Talairach-defined region.
Overview generated by GPT-4o (2026).
Region ID: 682
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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