The bilateral Left Cerebrum.Frontal Lobe.Rectal Gyrus in the Talairach labels 1 mm Atlas refers to frontal lobe tissue along the medial orbital surface, corresponding most closely to the rectus gyrus (also called the straight gyrus) on the inferior aspect of the frontal lobe. This region lies adjacent to the olfactory tract and gyrus, and forms part of the orbitofrontal cortex involved in affective processing, reward evaluation, decision-making, and integration of sensory and visceral information relevant to social and emotional behavior. It has strong connections with limbic structures, including the amygdala and hippocampus, and participates in networks that modulate autonomic responses and subjective emotional states. Although there is no dedicated Wikipedia article for “Rectal Gyrus” as labeled in this atlas, it is most closely related to the Orbitofrontal cortex.
The bilateral left rectal (gyrus rectus) region of the frontal lobe, as defined in the Talairach 1 mm atlas, has been implicated indirectly through imaging‑genetics and GWAS studies that examine orbitofrontal and ventromedial prefrontal cortex structure and function, rather than through locus-specific analyses, with heritability estimates showing substantial genetic influence on cortical thickness and volume in medial orbitofrontal areas that include the gyrus rectus. Large-scale brain MRI GWAS (e.g., ENIGMA and UK Biobank–based studies) have identified common variants near genes involved in neurodevelopment, synaptic signaling, and axonal guidance (such as MAPT, HMGA2, and several loci on chromosomes 3, 6, and 17) associated with orbitofrontal volume and surface area measures overlapping this region. Functionally, the gyrus rectus and adjacent medial orbitofrontal cortex have been linked via polygenic and candidate-gene studies to traits such as risk-taking, reward sensitivity, and mood regulation, and structural or functional abnormalities in this region appear in genetic or polygenic-risk contexts for major depressive disorder, bipolar disorder, schizophrenia, obsessive–compulsive disorder, and substance-use–related phenotypes, although findings tend to implicate broader orbitofrontal–ventromedial prefrontal circuits rather than the gyrus rectus alone and no single gene or variant is known to be uniquely or specifically associated with this Talairach-defined area.
Overview generated by GPT-4o (2026).
Region ID: 143
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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