The bilateral Left Cerebrum.Frontal Lobe.Rectal Gyrus.Gray Matter.Brodmann area 11 corresponds to gray matter within the medial orbitofrontal cortex, specifically involving the gyrus rectus (straight gyrus) along the ventral surface of the frontal lobe, adjacent to the olfactory sulcus and inferior to the rostral portion of the frontal pole. Brodmann area 11 is part of the prefrontal cortex and is implicated in higher-order integrative functions, including reward valuation, decision-making, emotional regulation, and aspects of social behavior, as well as modulation of autonomic and visceral responses. This region is heavily interconnected with limbic structures, including the amygdala and hippocampus, as well as other prefrontal and sensory association areas, supporting its role in integrating affective, sensory, and contextual information to guide goal-directed behavior and adaptive responses. There is no direct Wikipedia article for this exact composite label; a closely related structure is the Orbitofrontal cortex.
The bilateral left rectal (gyrus rectus) portion of Brodmann area 11 in the frontal lobe—part of the orbitofrontal cortex (OFC)—has been implicated in genetic studies primarily through broader OFC or ventromedial prefrontal cortex phenotypes rather than highly specific gyrus-rectus–only findings; GWAS and imaging-genetics work consistently link common variants in genes involved in synaptic function and neurodevelopment (for example, BDNF, COMT, SLC6A4, and dopaminergic and serotonergic pathway genes) to structural and functional differences in orbitofrontal and adjacent medial prefrontal regions that encompass BA11, including gray matter volume, cortical thickness, and connectivity. Large ENIGMA and UK Biobank–based analyses have identified polygenic influences on frontal lobe and OFC morphology, with genome-wide significant loci in genes related to neuronal proliferation, axon guidance, and myelination, and polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder show associations with altered medial/orbitofrontal volumes and surface measures that include BA11/rectal gyrus parcels. Additional studies link OFC/BA11 variation to genetic risk for anxiety traits, neuroticism, risk-taking, and substance use (notably alcohol and nicotine), while neurodegenerative and neurodevelopmental disorder genetics (e.g., Alzheimer’s disease and autism spectrum disorder risk loci) have been associated with patterns of atrophy or cortical alteration that include medial OFC/BA11, though these effects are typically reported at the level of broader frontal or orbitofrontal regions rather than the Talairach-defined “Left Cerebrum.Frontal Lobe.Rectal Gyrus.Gray Matter.Brodmann area 11” region alone.
Overview generated by GPT-4o (2026).
Region ID: 142
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
This resource is licensed under CC0 1.0 Universal (Public Domain).