The bilateral Left Cerebrum.Limbic Lobe.Anterior Cingulate.White Matter corresponds to the subcortical myelinated fiber pathways underlying the anterior cingulate gyrus, a key component of the limbic system. These white matter tracts connect the anterior cingulate cortex with prefrontal regions, motor areas, other cingulate zones, and subcortical structures such as the thalamus and limbic nuclei, supporting integration of cognitive control, emotion, autonomic regulation, and pain processing. As part of the larger cingulum bundle and adjacent frontal white matter, this region facilitates communication between medial frontal executive networks and limbic circuits involved in motivation, conflict monitoring, error detection, and affective regulation. There is no direct link for this exact white matter label; a related structure is the overlying Anterior cingulate cortex.
The anterior cingulate white matter, as defined in the Talairach 1 mm atlas within the limbic lobe of the left cerebrum, has been implicated in several genetic and genome-wide association studies that link its microstructural and volumetric properties to both common and rare variants affecting neurodevelopment, myelination, and synaptic function. Large-scale imaging genetics consortia (e.g., ENIGMA, UK Biobank–based GWAS) have identified associations between diffusion tensor imaging measures (such as fractional anisotropy and mean diffusivity) and variants near genes involved in axon guidance and myelin integrity (including NTRK3, CNTN4/6, and multiple oligodendrocyte-related loci), as well as polygenic influences related to general cognitive ability and educational attainment that partly act through cingulate white matter integrity. Genetic risk for major psychiatric disorders—including schizophrenia, bipolar disorder, and major depressive disorder—shows convergent effects on anterior cingulate white matter, with polygenic risk scores correlating with altered microstructure and reduced volume in this region, and CNVs such as 22q11.2 deletion affecting cingulate connectivity. In addition, common variants associated with chronic pain sensitivity, anxiety-related traits, and attention-deficit/hyperactivity disorder have been linked to structural and functional changes in anterior cingulate pathways, while neurodegenerative risk loci (e.g., APOE for Alzheimer’s disease) show secondary effects on cingulate white matter degeneration, underscoring this tract’s role as a genetically sensitive hub for emotion regulation, cognitive control, and interoceptive processing.
Overview generated by GPT-4o (2026).
Region ID: 371
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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