Brodmann area 24 of the cingulate gyrus, located within the limbic lobe of the left and right cerebrum, is a gray matter region forming part of the anterior cingulate cortex (ACC), arching around the corpus callosum on the medial surface of the frontal lobe. It is cytoarchitectonically defined by a dysgranular to agranular cortical organization and is heavily interconnected with prefrontal, motor, limbic, and autonomic centers. Functionally, this region contributes to emotional processing, conflict monitoring, error detection, motivation, and modulation of autonomic responses, integrating cognitive and affective information to influence decision-making and behavioral control. There is no direct link for this exact cytoarchitectonic label; a related structure is the Anterior cingulate cortex.
The bilateral left cerebrum limbic lobe cingulate gyrus gray matter Brodmann area 24 (BA24), corresponding largely to anterior cingulate cortex, has been implicated in numerous genetic and GWAS findings through its involvement in emotion regulation, cognitive control, and pain processing. Structural and functional variation in BA24 has been associated with common psychiatric disorders, including major depressive disorder, schizophrenia, bipolar disorder, anxiety disorders, and obsessive–compulsive disorder, with GWAS-identified risk loci in genes such as CACNA1C, ZNF804A, DRD2, and GRM3 often showing downstream effects on anterior cingulate activation or connectivity. Polygenic risk scores for schizophrenia and depression correlate with gray matter volume and functional responses in BA24, and variants in serotonin transporter (SLC6A4), BDNF (e.g., Val66Met), and COMT have been repeatedly linked to altered anterior cingulate structure and task-related activation in imaging genetics studies. Pain sensitivity and chronic pain conditions, including fibromyalgia and migraine, have been tied to BA24 function with genetic contributions from dopaminergic, opioid (OPRM1), and inflammatory pathway genes influencing cingulate responses to nociceptive stimuli. GWAS of cognitive and personality traits (such as neuroticism, impulsivity, and cognitive control) also implicate BA24 circuitry, with associated loci affecting synaptic plasticity and glutamatergic signaling that modulate anterior cingulate morphology and connectivity, underscoring BA24 as a key genetically influenced hub in affective and cognitive psychopathology.
Overview generated by GPT-4o (2026).
Region ID: 941
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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