The bilateral Left Cerebrum.Limbic Lobe.Sub-Gyral.Gray Matter.Brodmann area 32 corresponds primarily to the subcortical portions of the dorsal anterior cingulate cortex (dACC), a medial prefrontal/limbic region situated within the cingulate gyrus above the corpus callosum. Brodmann area 32 is characterized by agranular to dysgranular cortex and dense connections with limbic, prefrontal, and premotor regions, integrating emotional, autonomic, and higher-order cognitive information. Functionally, this area is implicated in conflict monitoring, cognitive control, error detection, decision-making under uncertainty, and regulation of affect and autonomic responses, including modulation of cardiovascular and visceromotor activity. Bilateral involvement emphasizes its role in coordinated interhemispheric processing of motivation, attention, and goal-directed behavior as part of broader limbic and fronto-parietal control networks. Anterior cingulate cortex
Brodmann area 32 in the left limbic sub-gyral gray matter (anterior cingulate/medial prefrontal region) has been repeatedly implicated in genetic studies of psychiatric and cognitive phenotypes, although most findings derive from imaging–genetics and GWAS of traits rather than direct GWAS of the Talairach-defined region itself. Common variants in genes related to glutamatergic and monoaminergic signaling (for example, COMT, SLC6A4, DRD2, and GRM3) and in calcium-channel and synaptic genes (such as CACNA1C and ZNF804A) have been associated with structural or functional alterations in this area, particularly in studies of risk for schizophrenia, bipolar disorder, major depressive disorder, and anxiety. Large-scale GWAS of cortical thickness and surface area have identified polygenic influences from neuronal development and synaptic plasticity genes (including pathways involving BDNF and other neurotrophin-related loci) that modulate medial prefrontal/anterior cingulate morphology encompassing Brodmann area 32. Functional MRI genetics studies link risk alleles in genes such as 5-HTTLPR and FKBP5 to altered activation of this region during emotion regulation, reward, and conflict monitoring tasks, supporting a role in stress reactivity, neuroticism, and depression-related traits. Additionally, polygenic risk scores for schizophrenia, depression, and ADHD show associations with BA32 gray-matter measures and connectivity, suggesting that this region acts as a convergence point for distributed genetic risk affecting limbic-cognitive integration and mood regulation.
Overview generated by GPT-4o (2026).
Region ID: 1029
Hemisphere: bilateral
Atlas: Talairach labels 1mm
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Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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