The bilateral Left Cerebrum.Occipital Lobe.Fusiform Gyrus.White Matter corresponds to the deep myelinated fiber tracts underlying the fusiform gyrus in the occipitotemporal region of the left hemisphere, as defined in the Talairach labels 1 mm atlas. This white matter supports communication between primary and associative visual cortices and higher-order ventral visual stream regions involved in object, face, word, and category-specific recognition, linking occipital visual input with temporal and frontal processing areas. It contains portions of long association pathways such as the inferior longitudinal fasciculus and related fibers that integrate visual form information with memory and semantic networks, thereby contributing to complex perceptual and cognitive functions. There is no direct Wikipedia article for this specific white matter label; a closely related structure is the fusiform gyrus: Fusiform gyrus.
The bilateral left cerebrum occipital fusiform white matter (fusiform gyrus region in the Talairach 1 mm atlas) is not typically targeted as a standalone ROI in genetic studies, but converging imaging‑genetics and GWAS work implicates genes and variants influencing fusiform structure, connectivity, and associated functions such as face and word recognition. Common variants in genes involved in neurodevelopment and synaptic plasticity (e.g., BDNF, NRG1, CNTNAP2, and candidate risk genes for autism spectrum disorder and schizophrenia) have been associated with fusiform gray–white matter morphology, altered fusiform activation, and disrupted structural connectivity, particularly in disorders characterized by social and visual processing deficits. GWAS of subcortical and cortical MRI measures (e.g., ENIGMA and UK Biobank) have identified polygenic influences on occipito‑temporal and fusiform thickness/volume, implicating loci related to neuronal migration, axon guidance, and myelination, though these findings are often reported at lobar or larger temporal–occipital parcel levels rather than specifically “Left Cerebrum.Occipital Lobe.Fusiform Gyrus.White Matter.” Genetic risk for autism, dyslexia, and prosopagnosia has been linked to atypical fusiform development and white‑matter tracts (such as the inferior longitudinal fasciculus) coursing through or adjacent to fusiform regions, while schizophrenia and major depression polygenic risk scores show associations with occipito‑temporal white‑matter microstructure in large diffusion MRI cohorts. Overall, genetic associations are better established for fusiform‑related functions and broader occipito‑temporal networks than for this exact Talairach white‑matter label, but existing GWAS and imaging‑genetics evidence supports a polygenic architecture influencing fusiform connectivity and susceptibility to neurodevelopmental and psychiatric disorders.
Overview generated by GPT-4o (2026).
Region ID: 206
Hemisphere: bilateral
Atlas: Talairach labels 1mm
Full Quality Version: Download MP4
Full Quality Version: Download MP4
Wali Sidiqyar*, Gaurav Rudravaram*, Elyssa M. McMaster, Trent M. Schwartz, Adam M. Saunders, Kurt G. Schilling, Bennett A. Landman "Introducing SPINS: A Shared Public Visualization Library of Neuroanatomical Structures." Medical Imaging with Deep Learning- short paper
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